Results 71 to 80 of about 610,754 (289)

Computer-based image analysis in breast pathology

open access: yesJournal of Pathology Informatics, 2016
Whole slide imaging (WSI) has the potential to be utilized in telepathology, teleconsultation, quality assurance, clinical education, and digital image analysis to aid pathologists.
Ziba Gandomkar   +2 more
doaj   +1 more source

Computer-based materials: a study of learner autonomy and strategies [PDF]

open access: yes, 2007
This paper reports on a study which examines the extent to which specified cognitive, social, and metacognitive strategies, are used by language students when working with computer-based materials (CBMs), in self-study contexts outside of the language ...
Figura, KA, Jarvis, HA
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Developing Computer Assisted Learning Media For Environment Education In Adiwiyata Elementary School [PDF]

open access: yes, 2016
: This research aims to: (1) identify systematic steps in developing computer assisted learning media for environment education in Adiwiyata elementary school, (2) know user (teacher and student) responds on visual aspect of the developed learning media,
Dirawan Darma, Gufran   +3 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Book Review: Computer-Assisted Language Learning in the Global South: Exploring Challenges and Opportunities for Students and Teachers

open access: yesThe EUROCALL Review
Computer-Assisted Language Learning in the Global South: Exploring Challenges and Opportunities for Students and Teachers Edited by Lee McCallum and Dara Tafazoli Published in 2024 by Taylor & Francis Pages: 230 DOI: https://doi.org/10.4324 ...
Harsha Dulari Wijesekera
doaj   +1 more source

Contextual Teaching with Computer-Assisted Instruction [PDF]

open access: yes, 2010
Computer technology has made substantial contributions to education and educators are now confronted with determining how to best incorporate it as a teaching tool. Educators have also long struggled with how to make what is learned in school more useful
Leach, Lynn, Putnam, A R
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The Visual Elements of Computer-based Language Assessment: Aspects and Effects

open access: yesStudies in Applied Linguistics & TESOL, 2012
The advent of computers and computer assisted technologies has certainly influenced many aspects of our personal and professional lives. The field of second language education is no exception, where such technologies first exerted their influence on ...
Sarab Al-Ani
doaj   +1 more source

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