Results 51 to 60 of about 607,220 (287)

Harnessing Higher-Order (Meta-)Logic to Represent and Reason with Complex Ethical Theories [PDF]

open access: yes, 2019
The computer-mechanization of an ambitious explicit ethical theory, Gewirth's Principle of Generic Consistency, is used to showcase an approach for representing and reasoning with ethical theories exhibiting complex logical features like alethic and ...
A Gewirth   +16 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

DEVELOPMENT OF COMPUTER AIDED DESIGN OF CHAIN COUPLING

open access: yesInternational Journal of Advanced Studies, 2015
The present paper describes the development stages of computer-aided design of chain couplings. The first stage is the automation of traditional design techniques (intermediate automation).
Sergey Aleksandrovich Sergeev
doaj  

A Criteria Transformation Approach to Pattern Matching based on Non-Linear Parameter Optimization

open access: yesJournal of Intelligent Systems, 2015
This paper presents a concept for pattern matching based on a parameter optimization system for approximative numerical calculation of some parameter combination under soft and hard constraints. The concept uses a non-linear parameter optimization method
John Christian   +4 more
doaj   +1 more source

Image Processing Algorithms Used in Robotics Applications

open access: yesCommunications, 2000
The paper presents the results obtained in implementing image-processing algorithms (edge detection, contour closing, skeletonizing). Several classical as well as two original algorithms are presented, together with sample images from the implementation.
Gheorghe Lazea, Alin Muresan, Emil Lupu
doaj   +1 more source

Variable angle photoelectron spectrometer [PDF]

open access: yes, 1977
The design, construction, and performance of a spectrometer for measuring the angular and energy distributions of electrons photoejected by rare gas resonance light is described. Results using 584.4‐Å photons from a helium lamp are reported.
Kuppermann, Aron   +2 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Automatization of Measurements of Photoelectric Parameters of High Impedance Semiconductor Films

open access: yesФізика і хімія твердого тіла, 2019
A method for measuring the electrical conductivity and photoconductivity of semiconductor films with high electrical resistance is described. An electric circuit is presented and a computer program is developed.
B. S. Dzundza   +3 more
doaj   +1 more source

Impact of computer training on professional library activities in Pakistan [PDF]

open access: yes, 2001
Report on a survey of alumni of the Pakistan Library Association’s Computer Training Center in Lahore to determine the impact of the Certificate in Library Automation (CLA) on librarianship in Pakistan.
Mahmood, Khalid, Sharif, Ashraf
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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