Results 61 to 70 of about 3,410,221 (285)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Remote Sensing, 2020 This article formulates the concept of games in the field of process control theory in marine sciences and reviews the literature on the possible applications of games. The possible types of game control processes for moving objects are presented.
Józef Lisowski
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Excessive computer game playing : evidence for addiction and aggression? [PDF]
, 2007 Computer games have become an ever-increasing part of many adolescents’ day-to-day lives. Coupled with this phenomenon, reports of excessive gaming (computer game playing) denominated as “computer/video game addiction” have been discussed in the popular ...
Griffiths, MD +2 more
core
Designing Tommy and Pokina Educative Language Game Software: a Transnational Popular Culture Project
SISFORMA, 2019 Products of popular culture are many. One of those is educative language game software. Not only is a game useful in combating boredom, but a game can increase someone’s education capability.
Ekawati Marhaenny Dukut +2 more
doaj +1 more source
Computing Game Values for Crash Games [PDF]
, 2007 We consider crash games which are a generalization of parity games in which the play value of a play is an integer, -∞ or ∞. In particular, the play value of a finite play is given as the sum of the payoffs of the moves of the play. Accordingly, one player aims at maximizing the play value whereas the other player aims at minimizing this value. We show
Thomas Gawlitza, Helmut Seidl
openaire +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Designs for Learning, 2009 The use of commercial, off-the-shelf computer games as teaching tools is an interesting possibility, but one that may alter the teacher’s role. Unlike specially adapted, game-like educational software, students’ attitudes toward the learning potential of
Mats Wiklund, Love Ekenberg
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source