Results 91 to 100 of about 1,879,885 (315)
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Theoretical Computer Science for the Working Category Theorist [PDF]
arXiv, 2017 Theoretical computer science discusses foundational issues about computations. It asks and answers questions such as "What is a computation?", "What is computable?", "What is efficiently computable?","What is information?", "What is random?", "What is an algorithm?", etc.
arxiv
Generating Multimedia Components for M-Learning [PDF]
The paper proposes a solution to generate template based multimedia components for instruction and learning available both for computer based applications and for mobile devices.
Adriana REVEIU +2 more
core
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Investigating the Intersection of Science Fiction, Human-Computer Interaction and Computer Science Research [PDF]
arXiv, 2018 This paper outlines ongoing dissertation research located in the intersection of science fiction, human-computer interaction and computer science. Through an interdisciplinary perspective, drawing from fields such as human-computer interaction, film theory and studies of science and technology, qualitative and quantitative content analysis techniques ...
arxiv
Cloudifying the Curriculum with AWS [PDF]
arXiv, 2020 The Cloud has become a principal paradigm of computing in the last ten years, and Computer Science curricula must be updated to reflect that reality. This paper examines simple ways to accomplish curriculum cloudification using Amazon Web Services (AWS), for Computer Science and other disciplines such as Business, Communication and Mathematics.
arxiv
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Getting Indexed by Bibliographic Databases in the Area of Computer Science [PDF]
, 2014 Every author and publisher is interested in adding their publications to the widely used bibliographic databases freely accessible in the world wide web: This ensures the visibility of their publications and hence of the published research.
Arne Kusserow, Sven Groppe
core
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source