Results 11 to 20 of about 75,255 (281)

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A [PDF]

Brazilian Journal of Medical and Biological Research, 2014
Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism.
Y. Wan, M.H. Tang, X.C. Chen, L.J. Chen, Y.Q. Wei, Y.S. Wang   +5 more
doaj   +3 more sources

Thymoquinone Attenuates Immune Mediated Liver Injury Induced by Concanavalin A in Mice

Iraqi Journal of Pharmaceutical Sciences, 2021
Autoimmune hepatitis is an inflammatory disease and its incidence has been increasing. The features of hepatitis are the release of inflammatory cytokines, the elevation of AST and ALT, and hepatocyte apoptosis and necrosis.
Halla A. Ahmad, Sarmed H. Kathem
doaj   +1 more source

Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization

Frontiers in Immunology, 2022
Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated hepatic injury remains limited.
Fenglian Yan, Fenglian Yan, Dalei Cheng, Dalei Cheng, Haiyan Wang, Haiyan Wang, Min Gao, Junfeng Zhang, Junfeng Zhang, Hongyan Cheng, Hongyan Cheng, Changying Wang, Changying Wang, Hui Zhang, Hui Zhang, Huabao Xiong, Huabao Xiong   +16 more
doaj   +1 more source

Reversibility of cell surface label rearrangement [PDF]

, 1976
Cell surface labeling can cause rearrangements of randomly distributed membrane components. Removal of the label bound to the cell surface allows the membrane components to return to their original random distribution, demonstrating that label is ...
Brown, Susan Smith, Revel, Jean-Paul
core   +1 more source

CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response

Frontiers in Pharmacology, 2022
Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li, Jing-Jing Wu, Jing-Jing Wu, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Xiu-Qin Li, Ting-Ting Chen, Mei-Fang Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun   +11 more
doaj   +1 more source

Depression Aggravates Immune-Mediated Hepatitis Through NLRP3 Overactivation Induced by Intestinal Microbiota. [PDF]

CNS Neurosci Ther
Depression is common in AIH patients and is associated with an elevated cirrhosis risk. AIH patients with depression, mice colonized with MDD microbiota, and ConA‐treated mice subjected to CUMS exhibit intestinal barrier dysfunction and hepatic NLRP3 inflammasome overactivation.
Zhou S, Guo L, Chen N, Liu H, Liu X, Li J, Dong S, Liu J, Wang X, Ran Y, Liu M, Chu H, Li Y, Yang H, Zhao J, Zhou L.   +15 more
europepmc   +2 more sources

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet, Christ, Michael, Eisen, Christoph, Theisen, Karl, Wehling, Martin   +4 more
core   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]

, 1984
Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core   +2 more sources

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux, AK Berntson, AK Steck, B Wiggert, Barbara Amann, BD McNeil, BM Spiess, C Eberhardt, C Kiel, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CA Deeg, CM Kalsow, Cornelia A. Deeg, CW Morgans, D Josic, D Schubert, ER Chapman, G Glavan, H de Wit, Hassan Y. Naim, HY Naim, J Petersen, J Ratelade, JK Zipplies, JP Collin, JW Becker, K Marino, KF Greif, KS Shamsi, LN Troelsen, Lucienne Chatenoud, M Mirshahi, M Takamori, M Takamori, M Takamori, M Takamori, M Vrljic, M Zhao, MA Koontz, Margarete E. Swadzba, MC Ehrenhofer, MC Kwok, MC Papadopoulos, ME Swadzba, MJ Lewis, N Martin-Moutot, P Ariel, P David, P Redecker, RA Levy, RL Degroote, RR Caspi, S Bohm, SM Hauck, SM Hauck, Stefanie M. Hauck, V Gauba, VA Lennon, VA Lennon, W Han, W Vennekate, XQ Liu, Y Wang   +68 more
core   +6 more sources