Results 51 to 60 of about 74,223 (272)

Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

Parasites & Vectors, 2019
Background Glycosylphosphatidylinositol is a surface molecule important for host-parasite interactions. Mannosyltransferase (GPI-14) is an essential enzyme for adding mannose on the glycosylphosphatidyl group.
Christiana Vargas Ribeiro, Bruna Fonte Boa Rocha, Douglas de Souza Moreira, Vanessa Peruhype-Magalhães, Silvane Maria Fonseca Murta   +4 more
doaj   +1 more source

Murine brain endothelial cells differently modulate interferon-γ and interleukin-17 production in vitro [PDF]

Archives of Biological Sciences, 2009
Brain endothelial cells (BEC) are the major constituents of the blood-brain barrier (BBB), the structure that controls entrance of immune cells into CNS parenchyma.
Momčilović Miljana, Miljković D., Mostarica-Stojković Marija   +2 more
doaj   +1 more source

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles [PDF]

, 2008
Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate
De Smedt, Stefaan, Demeester, Jo, Lentacker, Ine, Sanders, Niek, Vandenbroucke, Roosmarijn   +4 more
core   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study

Indian Journal of Ophthalmology, 2007
Background: Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy. Aims: The
Diaz-Gonzalez Juan, Mayoral-Chavez Miguel, Bohorquez Paulina, de la Torre del Pilar Gabriel, Hernandez-Cruz Pedro, Martinez-Cruz Ruth, Perez-Campos Eduardo   +6 more
doaj  

Fermented Lentinus edodes extract containing α-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice

Food Science and Human Wellness
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that threatens human health worldwide. The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containing α-glucan (FLA), in a concanavalin A ...
Xin Hu, Dan Cheng, Yingxia Zhang, Po Li, Xiaoping Wu, Junsheng Fu   +5 more
doaj   +1 more source

Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Cell Communication and Signaling, 2022
Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular ...
Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, Maria Jade Catalan Opulencia, Walid Kamal Abdelbasset, Dmitry Olegovich Bokov, Yasser Fakri Mustafa, Moaed E. Al-Gazally, Ali Thaeer Hammid, Mustafa M. Kadhim, Seyed Hossein Ahmadi   +10 more
doaj   +1 more source

In Vivo Toxicity of Concanavalin A

Experimental Biology and Medicine, 1974
SummaryCon A administered intravenously in doses of 200-800 μg produced atrophy of lymphoid tissues, vascular endothelial damage and focal hepatic necrosis. At the highest dose given, up to 30% of the mice died within two days of what appeared to be acute hepatic failure. The injection of up to 2000 μg Con A ip produced only local inflammatory changes.
openaire   +3 more sources

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Extraction and Purification of Laccases from Rice Stems

Bio-Protocol, 2019
Laccases are found in cell walls of plants in very low amounts. This protocol provides an efficient method to purify laccases from rice stems. The method involves three steps: 1) Isolation of total protein from rice stems using buffers with high salt ...
Chenna Swetha, Padubidri Shivaprasad
doaj   +1 more source