A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]
, 2009 Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn +11 more
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The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells [PDF]
, 2007 Upregulation of functional voltage-gated Na+ channels (VGSCs) occurs in metastatic human breast cancer (BCa) in vitro and in vivo. The present study aimed to ascertain the specific involvement of the 'neonatal' splice variant of Nav1.5 (nNav1.5), thought
Brackenbury, William J. +3 more
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Food Science and Human WellnessAutoimmune hepatitis (AIH) is a chronic inflammatory liver disease that threatens human health worldwide. The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containing α-glucan (FLA), in a concanavalin A ...
Xin Hu +5 more
doaj +1 more source
Magnesium Isoglycyrrhizinate Ameliorates Concanavalin A-Induced Liver Injury by Inhibiting Autophagy
Frontiers in Pharmacology, 2022 Background and Aims: Acute liver failure (ALF) is a type of liver injury that is caused by multiple factors and leads to severe liver dysfunction; however, current treatments for ALF are insufficient.
Zihao Fan +9 more
doaj +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 The aim of present study was to develop the efficient targeting of Concanavalin-A conjugated nanotransfersomal gel to bind directly to melanocytes gel layer against UVB induced skin carcinoma.
Manmohan S. Jangdey +2 more
doaj +1 more source
Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
, 1985 The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina, +8 more
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The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture
Brazilian Archives of Biology and Technology, 2002 Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S. +7 more
doaj
Activation of concanavalin A by Cd2+.
Journal of Biological Chemistry, 1980 Binding of Cd2+ to concanavalin A and the subsequent induction of saccharide-binding activity has been studied at pH 6.5. We found that Cd2+ bound to both metal sites, S1 and S2, and that Cd2+ alone would induce sugar binding in concanavalin A. Using the fluorescent sugar 4-methylumbelliferyl alpha-D-mannopyranoside we determined that full saccharide ...
James A. Magnuson +4 more
openaire +3 more sources
Effect of synthetic and bovine milk conjugated linoleic acid (CLA) on immune function : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nutrition Science at Massey University [PDF]
, 1999 CLA is a collective name for a mixture of positional and geometrical isomers of linoleic acid (c-9, c-12-octadecadioenic acid) which possess conjugated double bonds.
Zhao, Hui
core
The crystal structure of Canavalia brasiliensis lectin suggests a correlation between its quaternary conformation and its distinct biological properties from Concanavalin A [PDF]
, 1997 Canavalia brasiliensis lectin was isolated from the seeds of a Brazilian autochthonous Leguminosae plant. Despite extensive amino acid sequence similarity with Concanavalin A, C.
Calvete, Juan J +4 more
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