Results 71 to 80 of about 73,159 (258)

Efficacy of Concanavalin-A conjugated nanotransfersomal gel of apigenin for enhanced targeted delivery of UV induced skin malignant melanoma

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The aim of present study was to develop the efficient targeting of Concanavalin-A conjugated nanotransfersomal gel to bind directly to melanocytes gel layer against UVB induced skin carcinoma.
Manmohan S. Jangdey, Chanchal Deep Kaur, Swarnlata Saraf   +2 more
doaj   +1 more source

Altered Glycosylation of PSA in Prostate Cancer Tissue

The Prostate, EarlyView.
ABSTRACT Background The glycosylation of proteins is commonly altered in cancer. This offers novel opportunities for cancer biomarker development. As prostate‐specific antigen (PSA) is a glycoprotein, identification of cancer‐specific PSA‐glycoforms is feasible. Such PSA‐glycoforms may provide valuable diagnostic and prognostic information. Methods PSA‐
Hannu Koistinen, Ruusu‐Maaria Merivirta, Timo‐Pekka Lehto, Anna Lempiäinen, Andrew Erickson, Ulf‐Håkan Stenman, Antti Rannikko, Tuomas Mirtti   +7 more
wiley   +1 more source

The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture

Brazilian Archives of Biology and Technology, 2002
Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S., Botelho Maria Valéria J., Lauretti Flávio, Melo Fernando L. de, Orlandi Janaina M., Linhares Rosa Elisa C., Ueda Marli, Nozawa Carlos M.   +7 more
doaj  

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

Cell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu, Yawen Tang, Wei Zhao, Juan Liu, Zhize Liu, Qianyin Yang, Meiqiang Chu, Jianhui Tian, Lei An, Shumin Wang   +9 more
wiley   +1 more source

Activation of concanavalin A by Cd2+.

Journal of Biological Chemistry, 1980
Binding of Cd2+ to concanavalin A and the subsequent induction of saccharide-binding activity has been studied at pH 6.5. We found that Cd2+ bound to both metal sites, S1 and S2, and that Cd2+ alone would induce sugar binding in concanavalin A. Using the fluorescent sugar 4-methylumbelliferyl alpha-D-mannopyranoside we determined that full saccharide ...
James A. Magnuson, D.J. Christie, J Fry, E R Pandolfino, Gerhard R. Munske   +4 more
openaire   +3 more sources

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

The FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika, Antonia Paić, Ana Novačić, Tea Martinić Cezar, Béatrice Vallée, Renata Teparić, Igor Stuparević, Bojan Žunar   +7 more
wiley   +1 more source

Blood group O expression in normal tissues and tumors

The FEBS Journal, EarlyView.
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4‐31L and OmcFL3‐02, specifically detect the H antigen on glycan microarrays, glycoproteins, and human cells.
Ea Kristine Clarisse Tulin, Lukas Muerner, Tanya R. McKitrick, Catherine A. Tilton, Lauren E. Pepi, Tianwei Jia, Maxence Noel, Leon Y. Zheng, Sean R. Stowell, Stephan von Gunten, Jamie Heimburg‐Molinaro, Richard D. Cummings   +11 more
wiley   +1 more source

Biomacromolecular stereostructure mediates mode hybridization in chiral plasmonic nanostructures [PDF]

, 2016
The refractive index sensitivity of plasmonic fields has been exploited for over 20 years in analytical technologies. While this sensitivity can be used to achieve attomole detection levels, they are in essence binary measurements that sense the presence/
Affar S. Karimullah, Barron L. D., Calum Jack, Fasman G. D., Graeme Cooke, Laurence D. Barron, Malcolm Kadodwala, Nikolaj Gadegaard, Ross Leyman, Ryan Tullius, Vincent M. Rotello   +10 more
core   +2 more sources

Galactosyltransferase and Concanavalin A Agglutination of Cells [PDF]

Proceedings of the National Academy of Sciences, 1974
A correlation has been observed between concanavalin A agglutination of various cell types and the presence of surface membrane galactosyltransferase (1- O -α-D-Galactosyl- myo -inositol:raffinose galactosyltransferase, EC 2.4.1.67) activity.
Kurt J. Isselbacher, J. Thomas La Mont, Daniel K. Podolsky, Milton M. Weiser   +3 more
openaire   +3 more sources

Imaging malaria parasites across scales and time

Journal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source