Results 81 to 90 of about 74,223 (272)

Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans, Van Renne, Nicolaas, Wei, Ruifang   +2 more
core   +1 more source

Activation of concanavalin A by Cd2+.

Journal of Biological Chemistry, 1980
Binding of Cd2+ to concanavalin A and the subsequent induction of saccharide-binding activity has been studied at pH 6.5. We found that Cd2+ bound to both metal sites, S1 and S2, and that Cd2+ alone would induce sugar binding in concanavalin A. Using the fluorescent sugar 4-methylumbelliferyl alpha-D-mannopyranoside we determined that full saccharide ...
James A. Magnuson, D.J. Christie, J Fry, E R Pandolfino, Gerhard R. Munske   +4 more
openaire   +3 more sources

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

Advanced Science, EarlyView.
Under endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). During the UPR, the cohesin complex at the promoter of cell proliferation‐related genes undergoes K29‐linked ubiquitination, recruiting the cohesin release factor WAPL to release cohesin, leading to transcriptional downregulation and inhibition of cell growth ...
Qiushuang Zhang, Xucong Teng, Yicong Dai, Yuncong Wu, Hongwei Hou, Jinghong Li   +5 more
wiley   +1 more source

A comparison of insulin binding by liver plasma membranes of rats fed a high glucose diet or a high fat diet

Journal of Lipid Research, 1977
The interaction of 125I-labeled insulin with purified liver plasma membrane from rats fed a high fat (L) diet or a high glucose (G) diet was studied with respect to specific binding, insulin degradation, binding site degradation, and rate of hormone ...
J V Sun, H M Tepperman, J Tepperman
doaj   +1 more source

Effect of floor type on the performance, physiological and behavioural responses of finishing beef steers [PDF]

, 2015
peer-reviewedBackground:The study objective was to investigate the effect of bare concrete slats (Control), two types of mats [(Easyfix mats (mat 1) and Irish Custom Extruder mats (mat 2)] fitted on top of concrete slats, and wood-chip to simulate deep ...
A O’Loughlin, AD Fisher, AD Fisher, AWMV Silva De, B Earley, B Earley, B Earley, B Earley, Barry McDonnell, Bernadette Earley, C Bergsten, C Bergsten, C Rouha-Muelleder, D Fraser, D Fraser, D Fraser, D Fraser, D Fraser, D Fraser, D Owens, DE Lowe, DJ Mellor, DM Broom, DM Broom, Edward G. O’Riordan, EFSA, EFSA, EFSA, EM Lynch, G Cozzi, GB Scott, H Irps, H Murata, H Schulze Westerath, I Veissier, J Hannan, J Hultgren, J Rushen, J Vanegas, JA Fregonesi, JH Britt, JNA Tilley, KE Schütz, KE Schütz, KL Graunke, KR Buckham Sporer, L Désiré, M Mazurek, MJ Hotzel, ML Jones, MRP Elmore, OM Radostits, PD Eckersall, PR Greenough, PV Kremer, S Gupta, TM Hill   +56 more
core   +1 more source

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source

Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture. [PDF]

, 1985
Previous studies (Neff et al., 1982, J. Cell. Biol. 95:654-666; Decker et al., 1984. J. Cell. Biol. 99:1388-1404) have described a monoclonal antibody (CSAT Mab) directed against a complex of three integral membrane glycoproteins of 120,000-160,000 mol ...
Bradley, D, Buck, CA, Damsky, CH, Horwitz, AF, Knudsen, KA   +4 more
core   +1 more source

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

Aggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang, Yanyu Chen, Shile Wang, Kan Liu, Xing‐Zhong Zhao, Xiaobo Mao, Ben Zhong Tang, Lang Rao   +7 more
wiley   +1 more source

Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy

Frontiers in Immunology, 2018
Concanavalin A-induced autoimmune hepatitis is a well-established experimental model for immune-mediated liver injury. It has been widely used in the therapeutic studies of immune hepatitis. The in-depth analysis of dysregulated proteins from comparative
Qin Feng, Qin Feng, Jingchun Yao, Ge Zhou, Wenkai Xia, Jingang Lyu, Xin Li, Tao Zhao, Guimin Zhang, Guimin Zhang, Ningwei Zhao, Ningwei Zhao, Jie Yang, Jie Yang   +13 more
doaj   +1 more source