Results 131 to 140 of about 1,205,845 (301)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Injection of concentrated growth factors from plasma for treating large chronic lower-extremity ulcers defects

Frontiers in Bioengineering and Biotechnology
The treatment of chronic lower-extremity ulcers is challenging, with a high ulcer recurrence rate.In chronic wounds, the healing process is stagnated in the inflammatory phase, characterized by persistent activation of the innate immune response ...
Zhiqiang Zhang, Zhiqiang Zhang, Nan Cao, Nan Cao, Chaoqi Zuo, Chaoqi Zuo, Xuan Guo, Xuan Guo, Yilei Wu, Yilei Wu, Yongxia Liu, Yongxia Liu, Guoyan Liu, Guoyan Liu, Xueqing Wang, Xueqing Wang, Shengji Zhou, Haixia Wang, Haixia Wang, Guangliang Zhang, Guangliang Zhang   +20 more
doaj   +1 more source

Strategic Mapping of the Rural Firm: A Balanced Scorecard Approach [PDF]

The present paper aims to propose an analysis and relation methodology of financial perspective, the customer perspective, the internal process perspective and the learning and growth perspective, in the same way as treated for Balanced Scorecard (BSC ...
Lourenzani, Wagner Luiz, Queiroz, Timoteo Ramos, Souza Filho, Hildo Meirelles de   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Autogenous Tooth Transplantation For Repair Of Oroantral Communication

International Dental Journal
Introduction: A case of successful autogenous tooth transplantation performed simultaneously to repair maxillary sinus communication following a tooth extraction, achieving favorable outcomes.
Zhenyong He, Bingke Guo
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Impact Of PPC Scaffolds On Alveolar Bone Defect In Rats

International Dental Journal
Aim or purpose: The purpose of this study was to construct a Polycaprolactone-Polyethyleneglycol-Concentrated growth factor ( PCL-PEG-CGF, PPC) composite scaffold, and to explore the biological safety of the scaffold and its effect on the repair of ...
Xin He, Yujie Jiang, Li Gao, Guangsheng Chen, Runan Wang, Jiajia Cheng   +5 more
doaj   +1 more source

On DDO154 and Cold Dark Matter halo profiles

, 1998
We investigate the claim by Burkert and Silk (1997) that the observed rotation curve of the dwarf irregular galaxy DDO154 cannot be reconciled with the universal CDM halo profile of Navarro, Frenk & White (1996,1997) even when allowance is made for the ...
Anderson, Binney, Burkert, Burkert, Carignan, Carignan, Carignan, Dubinski, Flores, Fukushige, Goldreich, Hernquist, Hoffman, Hopp, Jesper Sommer-Larsen, Kennicutt, Kravtsov, Maloney, Meurer, Mo, Moore, Moore, Navarro, Navarro, Navarro, Navarro, Sergio Gelato, Sommer-Larsen, Toomre, Van Zee, Verter   +30 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Income distribution in the Latin American Southern Cone during the first globalization boom, ca: 1870-1920 [PDF]

, 2008
Latin America is the most unequal region in the world and there is a lively debate concerning the explanations and timing of such high levels of income inequality.
Bértola, Luis, Castelnovo, Cecilia, Rodríguez, Javier, Willebald Remedios, Henry Francisco   +3 more
core   +1 more source