Results 141 to 150 of about 15,301 (254)

Tracing the origin of myofibroblasts in kidney fibrosis. [PDF]

Nat Commun
He S, Xia T, Guo Z, Song X, Wang H, He H, Jia K, Chen R, Zhou B, He L.   +9 more
europepmc   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen. [PDF]

Nat Commun
Aagaard JB, Gandini R, Ballegaard AR, Jensen BK, Dorn B, Larsen AVB, Lenstrup A, Sønderholm M, Miehe M, Pfützner W, Jakob T, Andersen GR, Möbs C, Spillner E.   +13 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Polymer Casting and Water Immersion-Based Large-Area Graphene Transfer for Flexible Electronics Fabrication. [PDF]

ACS Appl Mater Interfaces
Zuccaro A, Simsar EG, Addai Asante N, Dogruel T, Wang L, Malakalapalli T, Kidambi PR, Erbil Abaci H, Damaser M, Uz M.   +9 more
europepmc   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus. [PDF]

J Extracell Vesicles
Madhu LN, Kodali M, Rao S, Attaluri S, Upadhya R, Shankar G, Shuai B, Somayaji Y, Ganesh SV, Kumar VS, James JE, Shetty PA, LeMaire A, Rao X, Cai JJ, Shetty AK.   +15 more
europepmc   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain. [PDF]

Neurol Genet
Ghovanloo MR, Effraim PR, Tyagi S, Aldrich AM, Yuan JH, Schulman BR, Jacobs DS, Dib-Hajj SD, Waxman SG.   +8 more
europepmc   +1 more source

Extended Strahler Ordering to Distinguish Mapped River Channels From Overland Flow Pathways and Consistently Compare Digital Networks

River Research and Applications, EarlyView.
ABSTRACT Digital networks are virtual representations of freshwater systems that provide important inputs to, and mapping of, river classifications, simulation models, and quantitative data analyses for policy, planning, and management. Strahler order has often been used to characterize network configuration and as a proxy indicator of river channel ...
Doug Booker, Matt Wilkins, Clare Wilkinson, Rachel Smith   +3 more
wiley   +1 more source