Results 161 to 170 of about 4,278 (250)

The REACHE Project: A Qualitative Co‐Production Project to Promote Inclusion of People With a Learning Disability in Health Care Research

open access: yesBritish Journal of Learning Disabilities, EarlyView.
ABSTRACT Background The REACHE project started in January 2023, when a group of nursing and allied health professional academic researchers from the University of Liverpool, people with learning disabilities and representatives from local learning disability support organisations (People First Merseyside and MOWLL) collaborated to co‐produce a short ...
Helen Marshall   +17 more
wiley   +1 more source

A Bayes factor framework for unified parameter estimation and hypothesis testing

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract The Bayes factor, the data‐based updating factor of the prior to posterior odds of two hypotheses, is a natural measure of statistical evidence for one hypothesis over the other. We show how Bayes factors can also be used for parameter estimation.
Samuel Pawel
wiley   +1 more source

Lodge moraines: a common yet underreported end‐moraine type—a review

open access: yesBoreas, EarlyView.
Lodge moraines are a distinct genetic type of end moraine formed by submarginal accretion of subglacial till; they are some of the largest end moraines in the world. Although underreported in the literature, they are of equal importance to push, dump and hummocky end moraines. End moraines are formed at glacier ice margins and show the extent of former
Mark D. Johnson   +11 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville   +6 more
wiley   +1 more source

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