Results 171 to 180 of about 4,278 (250)

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

The role of ribosomal protein networks in ribosome dynamics. [PDF]

Nucleic Acids Res
Timsit Y, Sergeant-Perthuis G, Bennequin D.   +2 more
europepmc   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Chalcogen substitution co-tunes photochromism and hydrogen bonding in semicarbazone photoswitches. [PDF]

Chem Sci
Sentürk B, Lekanne Deprez S, Hennesen W, Fonseca Guerra C, Eisenreich F.   +4 more
europepmc   +1 more source

Challenges and Coping Strategies of Migrant Parents in Türkiye: A Qualitative Study

Child &Family Social Work, EarlyView.
ABSTRACT This qualitative study explored the coping mechanisms used by 22 immigrant parents (nine men, 13 women) of Syrian, Iraqi, Afghan and Palestinian origin in Türkiye to cope with challenges related to food, shelter, healthcare and social exclusion while caring for their children.
Murat Altuntaş, Habibullah Akinci
wiley   +1 more source

Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins. [PDF]

J Am Chem Soc
Kompa J, Dornfeld LJ, Porzberg N, Jang S, Zedlitz S, Lilje SH, Catapano C, Jocher D, Merk L, Hoege C, Mao R, Wilhelm J, Dietz MS, Tarnawski M, Hiblot J, Hyman AA, Heilemann M, Johnsson K.   +17 more
europepmc   +1 more source

Impact of Transnational Family Separation on Parenting and Psychosocial Well‐Being for Black African Migrant Parents in Hamilton

Child &Family Social Work, EarlyView.
ABSTRACT In light of increased migration from sub‐Saharan Africa (SSA) to Hamilton in the past 5 years, this qualitative study explores the experiences of Black African migrant parents resettling in Hamilton, Canada. Using semi‐structured interviews and thematic analysis, four key themes emerged: (1) impact of migration and family separation stress on ...
Tsinat Semagn, Ingrid Waldron, Allison Williams, Olive Wahoush   +3 more
wiley   +1 more source

Effect of Screen Time on Language Development Among Toddlers and Preschool Children in Al Qatif, Saudi Arabia. [PDF]

Cureus
AlQurashi FO, Alshammasi H, Alhashim S, Alrebh Z, Almubarak A.   +4 more
europepmc   +1 more source

Narratives of Strength: Exploring Storytelling as a Tool for Resilience in Families

Child &Family Social Work, EarlyView.
ABSTRACT Resilience, originally viewed as a psychological capacity to ‘bounce back’ from challenges, is now understood to be shaped by broader social inequalities, including gender, socio‐economic status, politics and ethnicity. This study explores how stories and narratives can help nurture resilience and improve well‐being among those residing in an ...
Chandra Ramamurthy, Srilatha Juvva, Gregory Armstrong, Karl Andriessen   +3 more
wiley   +1 more source