Results 191 to 200 of about 5,268 (276)

The Chromaverse Is Colored by Triplexes Formed Through the Interactions of Noncoding RNAs with HNPRNPU, TP53, AGO, REL Proteins, Intrinsically-Disordered Regions, and Flipons. [PDF]

Int J Mol Sci
Herbert A.
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Perceptions of the 2D short animated videos for literacy against chronic diseases among adults with diabetes and/or hypertension: a qualitative study in primary care clinics. [PDF]

BMC Prim Care
Pichayapinyo P, Sompopcharoen M, Thiangtham W, Sillabutra J, Meekaew P, Bureerat B, Somboonkaew A.   +6 more
europepmc   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Chalcogen substitution co-tunes photochromism and hydrogen bonding in semicarbazone photoswitches. [PDF]

Chem Sci
Sentürk B, Lekanne Deprez S, Hennesen W, Fonseca Guerra C, Eisenreich F.   +4 more
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Mechanistic Basis of Cholesterol Binding and Transfer in NPC2: Insights From Molecular Dynamics Simulations. [PDF]

Chembiochem
Patel S, Elghobashi-Meinhardt N.
europepmc   +1 more source

Challenges and Coping Strategies of Migrant Parents in Türkiye: A Qualitative Study

Child &Family Social Work, EarlyView.
ABSTRACT This qualitative study explored the coping mechanisms used by 22 immigrant parents (nine men, 13 women) of Syrian, Iraqi, Afghan and Palestinian origin in Türkiye to cope with challenges related to food, shelter, healthcare and social exclusion while caring for their children.
Murat Altuntaş, Habibullah Akinci
wiley   +1 more source

The role of ribosomal protein networks in ribosome dynamics. [PDF]

Nucleic Acids Res
Timsit Y, Sergeant-Perthuis G, Bennequin D.   +2 more
europepmc   +1 more source

Impact of Transnational Family Separation on Parenting and Psychosocial Well‐Being for Black African Migrant Parents in Hamilton

Child &Family Social Work, EarlyView.
ABSTRACT In light of increased migration from sub‐Saharan Africa (SSA) to Hamilton in the past 5 years, this qualitative study explores the experiences of Black African migrant parents resettling in Hamilton, Canada. Using semi‐structured interviews and thematic analysis, four key themes emerged: (1) impact of migration and family separation stress on ...
Tsinat Semagn, Ingrid Waldron, Allison Williams, Olive Wahoush   +3 more
wiley   +1 more source