Results 81 to 90 of about 3,795,023 (266)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor

Angewandte Chemie, EarlyView.
Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker, Hongyu Wang, Kun Chen, Kristin Löbner, Karin Mörl, Simon Jonas Schwarz, Qiang Zhao, Beili Wu, Annette Gabriele Beck‐Sickinger   +8 more
wiley   +2 more sources

Exploring measurement estimation strategies through concept cartoons designed with Realistic Mathematics Education

Humanities & Social Sciences Communications
Concept cartoons, in relationship with Realistic Mathematics Education (RME), not only serve as a dynamic platform for problem-solving but also intricately weave mathematical concepts into the fabric of real-world scenarios, creating a harmonious fusion ...
Emel Çilingir Altiner
doaj   +1 more source

Holistic Development of Undergraduate Students – Concept Cartoons to Authentic Discovery [PDF]

Journal of Systemics, Cybernetics and Informatics, 2019
This paper describes a holistic pedagogical approach for classroom engagement. The project translates theory and fundamental classroom knowledge to authentic application with cutting edge research implemented by undergraduates at a Historically Black ...
Kausik S. Das, Larry Gonick, Monica Mitchell, Charles G. Baldwin, Moses Kairo   +4 more
doaj  

Observing students’ problem solving strategies in mechanics by eye-tracking method

Scientia in Educatione, 2018
The paper is focused on observation of students’ problem solving strategies when solving concept cartoons tasks testing their understanding of the 1st and 2nd Newton’s law.
Eva Hejnová, Martina Kekule
doaj   +1 more source

Customized Itinerant Frequency Combs by Cascaded Nonlinear Effects

Advanced Science, EarlyView.
A cascaded third‐order nonlinear system generates an itinerant frequency comb with the comb center frequency decoupled from the cavity resonance. This enables arbitrary spectral scaling, flexible spacing adjustments, and real‐time central‐frequency engineering, allowing comb splicing and subdivision. The resulting versatility and reconfigurability open
Yi Wang, Yulong Liu, Zeji Li, Wenyan Wang, Sihan Wang, Cheng Wang, Jingwei Zhou, Jie‐Qiao Liao, Tiefu Li   +8 more
wiley   +1 more source

Control of Helix Screw‐Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units

Angewandte Chemie, EarlyView.
Sequence‐diverse meso and “near‐meso” oligourea foldamers are reported and exhibit stimulus‐responsive helix screw‐sense control governed by terminal‐group desymmetrization and sequence‐encoded helix stability. ABSTRACT Meso oligoureas are dynamic hydrogen‐bonded foldamers capable of reversible helix polarity inversion but have so far been limited to ...
Naveen Gupta, Mégane Bornerie, Bo Li, Antoine Hacihasanoglu, Orlando Villegas Bello, Stéphanie Antunes, Estelle Morvan, Jean‐Marc Sotiropoulos, Philippe Carbonnière, Morgane Pasco, Brice Kauffmann, Céline Douat, Sung Hyun Yoo, Gilles Guichard   +13 more
wiley   +2 more sources

Political Dynasty Representation in The 2024 Presidential and Vice Presidential Election Candidates in Kompas Daily Editorial Cartoons

Ekspresi dan Persepsi: Jurnal Ilmu Komunikasi
Political dynasties have emerged as a significant concern in Indonesian politics, particularly in the context of the 2024 presidential election. This study aims to analyze the representation of political dynasties in editorial cartoons published by the ...
Antonius Sulistyo Prabowo, Bertha Sri Eko Murtiningsih, Ambang Priyonggo   +2 more
doaj   +1 more source

Cartoons

, 2020
Comparative Reflections on Cartoons as Snapshot, Narrative and Source. Throughout the 20th century, cartoons relentlessly appeared in all sorts of newspapers.
John Cafferkey (17154970), Jane Chapman (17155345), Kate Allison (17152819), Andrew Kerr (17161312)   +3 more
core   +3 more sources

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source