Results 81 to 90 of about 5,268 (276)
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Aufklärung, 2015 In this paper we analyze the concept of subjective violence and objective violence (“symbolic” violence of language) from Žižek (2014) and with the context Chalie Hebdo case here briefly investigated from his cartoons as rationality instrument of ...
Wellington Amâncio Da Silva +1 more
doaj +1 more source
An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity
Advanced Science, EarlyView.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
wiley +1 more source
Leren redeneren en experimenteren met concept cartoons
, 2012 Leren Redeneren en Experimenteren met Concept Cartoons.
Kruit, Patricia
core
Science in the early years: Concept cartoons as monitoring tools. Educator resource
, 2020 Cartoons can be used as a way of monitoring children’s developing understanding of concepts (‘concept cartoons’). Cartoons provide a simple narrative in which two or more characters provide commentary or opinions about a phenomenon. The cartoon format is
Australian Council for Educational Research
core
Advanced Science, EarlyView.This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu +10 more
wiley +1 more source
The Dusseldorf Illustrated Schema Questionnaire for Children (DISC)
Psicologia: Reflexão e Crítica, 2018 Childhood experiences are considered to be of crucial importance in the formation of maladaptive schemas, according to Young’s concept. Although some schema questionnaires already exist for children, these instruments differ in their schema structures ...
Christof Loose +2 more
doaj +1 more source
Adsorption of Forever Chemical Pollutants: The Physical Chemistry of PFAS Near Surfaces
Advanced Science, EarlyView.Current adsorption‐based remediation techniques for removing per‐ and polyfluoroalkyl substances (PFAS) from water are limited by knowledge gaps on PFAS behavior near solid surfaces. This review provides a state of the art on theoretical and experimental aspects of PFAS adsorption.
Nada Ben Amor +3 more
wiley +1 more source
CogniTextes, 2018 The present paper investigates the acquisition of one basic cognitive concept – the causativity. Using a cross-linguistic study on French and Bulgarian, we seek to understand which specificity of the causativity makes it difficult to acquire: its ...
Yanka Bezinska +2 more
doaj +1 more source
Advanced Science, EarlyView.Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo +4 more
wiley +1 more source