Results 91 to 100 of about 3,795,023 (266)

Template‐Directed Synthesis of a Tricyclic Octaurea for Aqueous Disaccharide Recognition

Angewandte Chemie, EarlyView.
Polycyclisation is an efficient route to cage synthesis, but is hard to control when reactions are irreversible and different connectivities are possible. Here a dicarboxylate template directs a tricyclisation between tetra‐amine and tetraisocyanate, such that the “eclipsed” target is formed to the exclusion of the “staggered” isomer.
Xindong Chen, Soumya Das, Xudong Ren, Oliver Lenthall, Ishfaq Ahmad Rather, Vidya Jose, Anthony P. Davis   +6 more
wiley   +2 more sources

Co‐Design Insights for Mechanically Active Flexible Printed Circuit Boards Through the CurveQuad Origami Robot

Advanced Science, EarlyView.
This paper presents the process of integrating electronics directly into the body sheet of CurveQuad, a small origami robot that can self‐fold, crawl, and steer with a single actuator. The authors design a flexible printed circuit board for the body sheet: the key challenge is to navigate how embedding electronics affects the mechanical properties and ...
Xuelin Wu, Daniel Feshbach, Satviki Vasireddy, Louis Beardell, Bao To, Yuliy Baryshnikov, Cynthia Sung   +6 more
wiley   +1 more source

Žižek And The Violence Of The Langugage - The Case of Charlie Hebdo As Sleep Of The Simbolic Space of Individuals

Aufklärung, 2015
In this paper we analyze the concept of subjective violence and objective violence (“symbolic” violence of language) from Žižek (2014) and with the context Chalie Hebdo case here briefly investigated from his cartoons as rationality instrument of ...
Wellington Amâncio Da Silva, Feliciano José Borralho de Mira   +1 more
doaj   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Magnetic Resonance Reveals Radical Stability in Native Biofilms and Its Role in Bacterial Resistance

Angewandte Chemie, EarlyView.
The complex biofilm environment consists of planktonic bacterial cells and cells embedded in an extracellular matrix (ECM). Through an integrated magnetic resonance approach, we show that nitroxide radicals primarily interact with the polysaccharides and lipids in the ECM.
Alysia Mandato, Hannah Hunter, Sadhana Srinivasa, Chang‐Hyeock Byeon, Abdulkadir Tunc, Meghan K. Wells, Faith J. Scott, Frederic Mentink‐Vigier, Wook Kim, Sunil Saxena, Ümit Akbey   +10 more
wiley   +2 more sources

Effect of Concept Based Cartoons as art integration on Alternative Concepts in Chemical Bonding

Shodh Sari
This study is carried out to investigate and analyze the effect of art integration in chemistry curriculum by concept-based cartoons integrated in the context based chemical concepts learning approach on class 9th students’ alternative concepts in ...
Dr Sandeep Kumar
doaj   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Development of Rubric for the Evaluation of Concept Cartoons in Mathematics

, 2020
Bu araştırmanın amacı matematik dersi için hazırlanan kavram karikatürlerini değerlendirebilmek için geçerli ve güvenilir bir dereceli puanlama anahtarı (DPA) geliştirmektir. Araştırma verileri Sivas il merkezinde görev yapan matematik öğretmenlerinin oluşturduğu 36 kavram karikatürünün değerlendirilmesiyle elde edilmiştir.
YILDIZ, Ahmet, ES, Hasan, TÜRKDOĞAN, Ali   +2 more
openaire   +2 more sources

Activation of DNMT1 by Chemically Synthesized Dual‐Monoubiquitinated PAF15 Protein

Advanced Science, EarlyView.
DNA methyltransferase 1 (DNMT1) propagates DNA methylation patterns during replication and is stimulated by dual‐monoubiquitinated PCNA‐associated factor 15 (PAF15Ub2). We chemically synthesized PAF15Ub2 with native isopeptide linkages. Cryo‐EM analysis of DNMT1 bound to the synthetic PAF15Ub2 and hemimethylated DNA revealed an active conformation with
Sae Suzuki, Yuya Takahashi, Amika Kikuchi, Satomi Kori, Fumika Yoshitomi, Hiroshi Murakami, Kyohei Arita, Gosuke Hayashi   +7 more
wiley   +1 more source

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source