Results 111 to 120 of about 22,041,249 (385)

Invisible design: exploring insights and ideas through ambiguous film scenarios [PDF]

, 2012
Invisible Design is a technique for generating insights and ideas with workshop participants in the early stages of concept development. It involves the creation of ambiguous films in which characters discuss a technology that is not directly shown.
Blythe, Mark, Briggs, Pamela, Dunphy, Paul, Green, David, Kitson, Jim, Lindsay, Stephen, Monk, Andrew, Nicholson, James, Olivier, Patrick, Vines, John   +9 more
core   +1 more source

THE CONCEPTUAL DESIGN OF A SUSTAINABLE REGIONAL AIRCRAFT

Journal of Industrial Design and Engineering Graphics, 2021
This paper aims to present the conceptual design of a sustainable regional aircraft. In previous studies, the hypothesis of this paper was determined: the purpose is to design a concept sustainable regional aircraft, propelled by electric engines ...
Ioana-Lidia MOTFOLEA
doaj   +2 more sources

Design concept for bolted Glass

Challenging Glass Conference Proceedings, 2010
For the design of load carrying glazing structures the connection technique plays an important role, as e.g. there are significant stress concentrations in the vicinity of holes that are subject to a point-like support of glass panes.
M. Baitinger, M. Feldmann
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The EU DEMO staged design approach in the Pre-Concept Design Phase

Fusion engineering and design, 2021
G. Federici, J. Holden, C. Baylard, A. Beaumont   +3 more
semanticscholar   +1 more source

The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges. [PDF]

Orphanet J Rare Dis, 2023
Haymond MW, Araújo-Vilar D, Balser J, Lewis JH, Louzado R, Musso C, von Schnurbein J, Wabitsch M, MEASuRE group.   +8 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Magnetohydrodynamic-based Internal Cooling System for a Ceramic Cutting Tool: Concept Design, Numerical Study, and Experimental Evalidation. [PDF]

Nanomanuf Metrol, 2023
O'Hara J, Fang F.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source