Results 91 to 100 of about 6,187,693 (341)

L’approche Living Lab : proposition et application d’une démarche méthodologique pour mieux prendre en compte les aspects humains dans la conception de produits logiciels [PDF]

open access: yes, 2012
Dans cet article, nous décrivons une démarche méthodologique de conception utilisant des technologies émergentes et s’inscrivant dans la continuité de l’approche Living Lab.
LOUP-ESCANDE, Emilie   +3 more
core  

Modulation of Ovarian Follicular Dynamics and Conception Rate in Buffalo Cows Exposed to Ovsynch Protocol Combined with a Recombinant Bovine Somatotropin

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
The objectives of this study were to elucidate the impact of the administration of recombinant bovine somatotropin (rbST), in combination with Ovsynch protocol on the preovulatory follicle (POF) diameter, a daily growth rate of the dominant follicle (DF),
Mohamed Mohsen Mansour   +1 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Effect of growth hormone on milk yield and reproductive performance of subfertile Holstein cows during extended lactations

open access: yesSpanish Journal of Agricultural Research, 2019
The objective of this study was to determine the effects of the administration of recombinant bovine somatotropin (rbST) throughout lactation to high-yielding subfertile (conception > 270 days postpartum) Holstein cows undergoing extended lactations ...
Jessica Flores   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Conception rate is associated with a locus on chromosome 6.

open access: yes, 2015
A. The distribution of conception rate among cows (females). B. The distribution of conception rate among sires. C. Manhattan plots for the genome-wide screen for loci associated with conception rate. The dotted line represents the threshold for a genome-
Yusaku Gotoh (765852)   +3 more
core   +1 more source

Angka Konsepsi Hasil Inseminasi Semen Cair Versus Semen Beku pada Kuda yang Disinkronisasi Estrus dan Ovulasi

open access: yesMedia Peternakan, 2010
Semen used for artificial insemination (AI) can be prepared in different ways, fresh extended fresh or chilled, or frozen-thawed (FT). The aim of the experiment was to evaluate the use of preserved semen to inseminate the oestrus mares.
R. I. Arifiantini   +4 more
doaj  

Effects of Semen Sexing Agent (Heifer-PlusTM) in Dairy Cow Reproduction

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
This study was conducted to investigate the use cryopreserved bovine sperm treated with Heifer-PlusTM Prefreeze kit and its effect on pregnancy rates calf sex ratio embryonic death, abortion, stillbirth and twinning rates in Holstein Friesian cows A ...
Constantin Găvan, Mihaela Riza
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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