Results 91 to 100 of about 2,244,720 (326)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Editorial: Transformable structures and envelopes in architecture and civil engineering
Frontiers in Built Environment, 2023 Marios C. Phocas, Maria Matheou
doaj +1 more source
Sketch-Based Interfaces to Support Collaborative Conceptual Design Learning [PDF]
, 2007 In order to gain a better understanding of online collaborative conceptual design processes this paper investigates how student designers make use of Lyceum, a shared virtual synchronous environment when engaged in conceptual design. The software enables
Aczel, James +3 more
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A conceptual design tool: Sketch and fuzzy logic based system [PDF]
, 2001 A real time sketch and fuzzy logic based prototype system for conceptual design has been developed. This system comprises four phases. In the first one, the system accepts the input of on-line free-hand sketches, and segments them into meaningful parts ...
Jordanov, IN, Qin, SF, Wright, DK
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Conceptual design summary [PDF]
, 1992 The Advanced Neutron Source (ANS) is a new basic and applied research facility based on a powerful steady-state research reactor that provides beams of neutrons for measurements and experiments in the fields of materials science and engineering, biology, chemistry, materials analysis, and nuclear science.
openaire +4 more sources
Solar sustained plasma/absorber conceptual design [PDF]
A space power system concept was evaluated which uses concentrated solar energy to heat a working fluid to temperatures as high as 4000 K. The high temperature working fluid could be used for efficient electric power production in advanced thermal or ...
Kendall, J. S. +2 more
core +1 more source
Conceptual design of harvesting energy system for road application [PDF]
, 2013 Energy harvesting becomes more and more important in our life. It refers to the practice of acquiring energy from the environment which would be otherwise wasted and converting it into usable electric energy.
Mihaj, Kamarul Faiz
core
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source