Results 61 to 70 of about 2,244,720 (326)

Supporting reinterpretation in computer-aided conceptual design [PDF]

, 2008
This paper presents research that aims to inform the development of computational tools that better support design exploration and idea transformation - key objectives in conceptual design.
AHRC (Funder), Chase, S., EPSRC (Funder), Garner, S., Jowers, I., Lim, S., McKay, A., Prats, M.   +7 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Preliminary Development of a Free Piston Expander–Linear Generator for Small-Scale Organic Rankine Cycle (ORC) Waste Heat Recovery System

Energies, 2016
A novel free piston expander-linear generator (FPE-LG) integrated unit was proposed to recover waste heat efficiently from vehicle engine. This integrated unit can be used in a small-scale Organic Rankine Cycle (ORC) system and can directly convert the ...
Gaosheng Li, Hongguang Zhang, Fubin Yang, Songsong Song, Ying Chang, Fei Yu, Jingfu Wang, Baofeng Yao   +7 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Lunar lander conceptual design [PDF]

This paper is a first look at the problems of building a lunar lander to support a small lunar surface base. A series of trade studies was performed to define the lander. The initial trades concerned choosing number of stages, payload mass, parking orbit
Adorjan, A. S., Chambers, T. V., Donofrio, M., Hirasaki, J. K., Morris, O. G., Nudd, G., Petro, A. J., Rawlings, R. P., Stecklein, J. M., Stump, W. R.   +9 more
core   +4 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Model-driven design, simulation and implementation of service compositions in COSMO [PDF]

, 2009
The success of software development projects to a large extent depends on the quality of the models that are produced in the development process, which in turn depends on the conceptual and practical support that is available for modelling, design and ...
Dirgahayu, Teduh, Quartel, Dick, Sinderen, Marten van   +2 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Improving Visual Comfort through Integrated Design in Architectural Education: A Performance Metrics Analysis of Adaptive Kinetic Facades

Architecture, Civil Engineering, Environment
This paper showcases three selected student projects on adaptive kinetic facades (AKFs) from the design studio “Smart Shade”, highlighting their influence on visual comfort, an essential component of occupants’ wellbeing and energy efficiency. Three case
Matheou Maria, Phocas Marios C.
doaj   +1 more source

Conceptual modeling in architecture: a creative and educational resource

Архитектон
Conceptual modeling is considered as a method of design activity and as a means of developing creative thinking in the process of architectural design.
Iovlev Valery I.
doaj   +1 more source