Results 61 to 70 of about 397,590 (315)

Comparing representations of geographic knowledge expressed as conceptual graphs

, 2005
. Conceptual Graphs are a very powerful knowledge and meaning rep-resentation formalism grounded on deep philosophical, linguistic and object oriented principles [1], [2].
Kavouras, M, Margarita Kokla, Marinos Kavouras, Kokla, M, Athanasios Karalopoulos, Karalopoulos, A   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Conceptual Model of Knowledge Evaluation via Knowledge Flow Manipulation [PDF]

, 2010
[[abstract]]Despite that knowledge management system has been extensively studied to attain potential solutions for business use, there has been less work in dealing with the knowledge evaluation.
Wu; Chien-Hsing;Chuan-Chun Wu ;Sen; Chi;Shih; Lan-Hsing;Wu;Ying-Yi
core  

Exploration of Spatial Abilities in Pre-Service Mathematics Teacher Education: Testing and Evaluation

Journal on Efficiency and Responsibility in Education and Science
Pre-service mathematics teachers often struggle with spatial ability, which negatively affects their success in solving geometric problems. Evaluating and developing these abilities is therefore an essential part of their university education. This paper
Petra Surynkova, Vlasta Moravcová, Jana Hromadová, Jarmila Robová   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

What are students expected to know? Comparing the intended integrated science curricula across 12 European countries

Cogent Education
Comparing the content of intended integrated science curricula across Europe provides valuable insights for countries seeking to design or reform integrated science curricula, a task that remains complex and challenging in many countries for curriculum ...
Michal Blaško, Svatava Janoušková, Eva Stratilová Urválková   +2 more
doaj   +1 more source

The Use of Pictorial Analogy to Increase Students’ Achievement and Its Retention of Physics Lessons of Direct Current

Jurnal Penelitian Fisika dan Aplikasinya, 2019
Analogy is considered a helpful way to help students visualize abstract concepts and assimilate new knowledge to an existing structure of cognitive.
Tomo Djudin, Selvaraj Grapragasem
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Hands-On and Virtual Laboratories in Electronic Circuits Learning—Knowledge and Skills Acquisition

Information
Hands-on and virtual laboratory-based learning has been integrated into science education due to its potential positive impact on students’ knowledge and skills development. In this study, we explore the effect of the hands-on and virtual laboratories on
Christos Tokatlidis, Sokratis Tselegkaridis, Sophia Rapti, Theodosios Sapounidis, Dimitrios Papakostas   +4 more
doaj   +1 more source