Results 71 to 80 of about 11,269 (252)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A case of using formal concept analysis in combination with emergent self organizing maps for detecting domestic violence. [PDF]
In this paper, we propose a framework for iterative knowledge discovery from unstructured text using Formal Concept Analysis and Emergent Self Organizing Maps.
Elzinga, Paul +3 more
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THE CONSTRUCTIVIST INSTRUCTION THROUGH CONCEPTUAL MAPS – A REVIEW OF THE LITERATURE [PDF]
, 2016 The constructivism, seen as a postmodern paradigm, discusses education based on classical and modern practices. Constructivist methods highlighted as a tool, the conceptual maps, an innovative learning method that captures the manner in which an ...
Oana DRĂGAN
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Polish Cartographical Review, 2017 The author presents an overview of the scope of content of selected topographic maps of Polish lands from the 19th and the first half of the 20th century in its quantitative aspect.
Panecki Tomasz
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ILO diagram: a novel conceptual model of intended learning outcomes
, 2014 Achieving intended learning outcomes (ILOs) in education is an ongoing topic within distance learning and educational communities. The term "ILOs" has been introduced to indicate what learners will be able to do by the end of the course of study ...
Tangworakitthaworn, Preecha
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THE CONCEPTUAL MAP SOLUTION TO THE PARADOX OF CONCEPTUAL ANALYSIS
IJRDO- Journal of Educational Research, 2023 Why do a conceptual analysis on a word that we already know how to use? Marilyn Strathern provides some information on garden cities and suburbs which suggests a novel solution to me.
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source