Results 91 to 100 of about 2,581,054 (298)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A conceptual model for assessing the level of development of Pilgrimage Routes

International Journal of Religious Tourism and Pilgrimage
This paper proposes an innovative conceptual model based on a hierarchical structure for the assessment of pilgrimage routes, establishing and weighting the different associated elements.
Vitor Ambrósio, Carlos Fernandes, Goretti Silva, Adília Cabral   +3 more
doaj   +1 more source

A framework for managing projects that integrate 4IR technologies

International Journal of Information Systems and Project Management
The Fourth Industrial Revolution (4IR) signifies a new phase in project management. The swift progression of 4IR technologies requires a reassessment of current methods to address the complexities of contemporary project management adequately.
Mothepane Tshabalala, Carl Marnewick
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Conceptual model of forming a proposal for providing communication to a unit using artificial intelligence

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The article discusses the problematic issue of the large time spent by a technical specialist when searching for options to provide communication to a unit in a new area.
Dmytro Havrylov, Roman Lukianiuk, Albert Lekakh, Olexandr Musienko, Vladymyr Startsev, Gennady Pris, Kyrylo Рasynchuk   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A conceptual model of foreign investment : a forestry internationalization case between New Zealand and Korea : a thesis presented in partial fulfillment of the requirements for the degree of Master of Agricultural Economics at Massey University [PDF]

, 1994
The purpose of this thesis is to explore comprehensive, strategic investment structure by examining the factor interactions revolving around the current issues which confront New Zealand forestry internationalisation in the global economic perspectives ...
Shin, Young-Woo
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A value oriented conceptual model for innovation in local government [PDF]

, 2007
The political rhetoric that accompanied the introduction of eGovernment expected it to produce innovation in the way government agencies conducted themselves with citizen and business alike.
Elliman, T, Kor, AL, Orange, G, Tassabehji, R   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source