Results 111 to 120 of about 24,842,000 (395)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Learning strategies: a synthesis and conceptual model

npj Science of Learning, 2016
The purpose of this article is to explore a model of learning that proposes that various learning strategies are powerful at certain stages in the learning cycle.
J. Hattie, Gregory M. Donoghue
semanticscholar   +1 more source

An Object-Oriented Framework for Explicit-State Model Checking [PDF]

, 2007
This paper presents a conceptual architecture for an object-oriented framework to support the development of formal verification tools (i.e. model checkers).
Kattenbelt, M., Rensink, A., Ruys, T.C.
core   +2 more sources

A Conceptual Model: The Impact of Sociodemographic on Coronary Heart Disease [PDF]

, 2020
The paper aims to examine the conceptual model on the impact of sociodemographic towards coronary heart disease. There is still limited study on the association between cost of living particularly the cost of food and housing and its impact on coronary ...
Azim, Zainal Azhar Zainal, Kassim, Aza Azlina Md, Mohamed, Juliza   +2 more
core  

Designing a conceptual model for environmental indices influencing the attendancy in urban spaces with an arid and hot climate: A case study of Hakim Street in Isfahan [PDF]

کاوش‌های جغرافیایی مناطق بیابانی, 2020
The climatic conditions in urban spaces with hot and arid regions always make it necessary to organize such spaces in urban planning and work out processes in proportion to the environmental conditions so that the quality of their attendancy can be ...
Kyoumars Habibi, Mostafa Behzadfar, Mehdi Saidi, Faezeh Torabinejad   +3 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A value oriented conceptual model for innovation in local government [PDF]

, 2007
The political rhetoric that accompanied the introduction of eGovernment expected it to produce innovation in the way government agencies conducted themselves with citizen and business alike.
Elliman, T, Kor, AL, Orange, G, Tassabehji, R   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Molecular Dynamics in a Grand Ensemble: Bergmann-Lebowitz model and Adaptive Resolution Simulation

, 2015
This article deals with the molecular dynamics simulation of open systems that can exchange energy and matter with a reservoir; the physics of the reservoir and its interactions with the system are described by the model introduced by Bergmann and ...
Agarwal, Animesh, Hartmann, Carsten, Site, Luigi Delle, Wang, Han, Zhu, Jinglong   +4 more
core   +1 more source