Results 111 to 120 of about 2,253,125 (238)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Point of View: A Holistic Four-Interface Conceptual Model for Personalizing Shock Resuscitation. [PDF]

J Pers Med
Rola P, Kattan E, Siuba MT, Haycock K, Crager S, Spiegel R, Hockstein M, Bhardwaj V, Miller A, Kenny JE, Ospina-Tascón GA, Hernandez G.   +11 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson's Disease. [PDF]

NPJ Parkinsons Dis
Mammen JR, Adams JL, Mangrum R, Xiao Y, Barbosa W, Tyo M, Redmond C, Carter C, Cifelli K, Cifelli R, Maruzo H, Meeker J, Shultz G, Thomas C, Bale C, Davies E, Kopil CM, Marras C, Mestre T, Morel T, Simuni T, Stebbins GT, Weintraub D, Stephenson D.   +23 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A conceptual model for dissolved P mobilization from legacy sources. [PDF]

J Environ Qual
Nash DM, Mc Dowell RW, Kleinman PJA, Moore PA, Duncan JM, Haygarth PM, Smith DR, Iho A.   +7 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

TWINVAX: conceptual model of a digital twin for immunisation services in primary health care. [PDF]

Front Public Health
De Oliveira El-Warrak L, Miceli de Farias C.   +1 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Conceptual model of pharmaceutical care for patients with coronary heart disease and comorbid conditions in Ukraine. [PDF]

J Pharm Policy Pract
Bilousova N.
europepmc   +1 more source