Results 71 to 80 of about 2,581,054 (298)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A Conceptual Model for Engineering Educators in Rural Places: Critical Reflection and Engagement

Studies in Engineering Education
Rural educational contexts often go under addressed in engineering education research and practice. Given the specific nuances associated with rural places and contexts, engineering education outreach should be better aligned with ongoing efforts to ...
Malle R. Schilling, Jacob R. Grohs
doaj   +1 more source

Conceptual Model for Developing Creativity in Batik Industry [PDF]

, 2010
The purpose of this research is to develop a conceptual model of creativity in batik industry. This model was developed by conducting a study from previous research that discuss important factors for the development of creativity.
Bakhtiar, Arfan, Sriyanto, Sriyanto, Susanty, Aries, Tambunan, Ruth D.   +3 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Lingvokognitivnyj analiz diskursa: ponâtijno-terminologičeskij apparat issledovaniâ

Stylistyka, 2019
This article is devoted to the linguistic and cognitive analysis of discourse. The article defines the basie terms and concepts, which are concepts and terminology by linguistic and cognitive analysis oť discourse, explores techniques for conceptual ...
Elena G. Malyševa
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

How do we acquire understanding of conceptual models? [PDF]

, 2015
In organizations, conceptual models are used for understanding the domain concepts. Such models are crucial in analysis and development of information systems.
Bera, Palash, Poels, Geert
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

LMODEL: A satellite precipitation methodology using cloud development modeling. Part I: Algorithm construction and calibration [PDF]

, 2009
The Lagrangian Model (LMODEL) is a new multisensor satellite rainfall monitoring methodology based on the use of a conceptual cloud-development model that is driven by geostationary satellite imagery and is locally updated using microwave-based rainfall ...
Bellerby, Tim, Hsu, Kuo Lin, Sorooshian, Soroosh   +2 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source