Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze+3 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Il nuovo modello concettuale dell’universo bibliografico: FRBR Library Reference Model
Il dibattito su FRBR library reference model qui esposto è basato sul testo 2016 destinato alla worldwide review. Si mettono in evidenza alcuni aspetti innovativi di FRBR-LRM rispetto ai precedenti modelli della famiglia FRBR e si espongono alcune ...
Pat Riva
doaj +1 more source
An Integrated Method for Determination of the Oswald Factor in a Multi-Fidelity Design Environment [PDF]
Aircraft conceptual design often focuses on unconventional configurations like for example forward swept wings. Assessing the characteristics of these configurations usually requires the use of physic based analysis modules.
Böhnke, Daniel+5 more
core
Periodic Orbits for a Discontinuous Vector Field Arising from a Conceptual Model of Glacial Cycles
Conceptual climate models provide an approach to understanding climate processes through a mathematical analysis of an approximation to reality. Recently, these models have also provided interesting examples of nonsmooth dynamical systems.
Hahn, Jonathan+3 more
core +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Development and application of a rainfall-runoff model for semi-arid regions
Despite the advances undertaken in recent years, modeling watershed’s hydrological responses remains a complex task, especially in data-scarce areas. In order to overcome this, new models with distinct representations of hydrological processes continue ...
José Almir Cirilo+5 more
doaj +1 more source
Interacting Conceptual Spaces [PDF]
We propose applying the categorical compositional scheme of [6] to conceptual space models of cognition. In order to do this we introduce the category of convex relations as a new setting for categorical compositional semantics, emphasizing the convex structure important to conceptual space applications.
arxiv +1 more source
Finite automata models of quantized systems: conceptual status and outlook [PDF]
Since Edward Moore, finite automata theory has been inspired by physics, in particular by quantum complementarity. We review automaton complementarity, reversible automata and the connections to generalized urn models.
Svozil, Karl
core +4 more sources
Models of Schizotypy: The Importance of Conceptual Clarity.
The observation of psychosis-like traits that resemble symptoms of schizophrenia and bipolar disorder, both among healthy relatives of psychotic patients and among the general population, can be traced to the early 20th century.1,2 These traits have ...
P. Grant, Melissa J. Green, O. Mason
semanticscholar +1 more source