Results 91 to 100 of about 2,725,308 (288)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
COGNITIVE LINGUISTIC CORRELATES BETWEEN LANGUAGE AND MORAL EDUCATION: INSIGHTS FROM GERMAN
Вісник Київського національного лінгвістичного університету. Серія: ФілологіяMorality is commonly regarded in public consciousness as a construct shaped by religious, legal, philosophical, and social dimensions. Although explicit discussions of morality are relatively rare in everyday discourse, linguistic expressions often ...
І. G.Lechner, І. І. Huszti
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Social Ontology, 2017 Is there a choice in sexual orientation? [Wilkerson, William S. (2009): “Is It a Choice? Sexual Orientation as Interpretation”. In: Journal of Social Philosophy 40. No. 1, p. 97–116] argues that sexual desires require interpretation in order to be fully
Saray Ayala
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Coding Process and Its Challenges
Grounded Theory Review: An International Journal, 2010 Coding is the core process in classic grounded theory methodology. It is through coding that the conceptual abstraction of data and its reintegration as theory takes place.
Judith A. Holton, Ph.D.
doaj +2 more sources
Conceptualizing Meaningful Experiences
Journal of Hospitality & Tourism ResearchDespite increased interest in experience and experience design in hospitality, tourism, and leisure, the field remains emergent. For experience design to mature in research and practice, clear consensus conceptualization of key constructs, like memorable, meaningful, and transformative experiences, is needed. While existing research identifies emotions
Marcel Bastiaansen, Mat D. Duerden
openaire +3 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Review and Recognition of the Book “Political Modernity and Review” [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2018 The political modernity is a book about the secularism and secular values. The author believes that current problems of society have roots in dedifferentiation between public and private sphere state and civil society and individuals and citizens.
Seyed Ebrahim Sarparast Sadat
doaj
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source