Results 101 to 110 of about 2,725,308 (288)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Systematicity in the Metaphorical Conceptualization of Knowledge based on Visual Perceptions in Ain al-Quzat Hamedani’s Tamhidat va Nameh-ha: A Cognitive Approach [PDF]

Matn/Pizhūhī-i Adabī
The aim of the present research is to explain the existence of systematicity in the metaphorical conceptualization of knowledge based on visual perceptions in Ain al-Quzat Hamedani’s Tamhidat va Nameh-ha.
Alireza Hajiannezhad, Mona Babaei
doaj   +1 more source

A Formal Context Representation Framework for Network-Enabled Cognition

, 2010
Network-accessible resources are inherently contextual with respect to the specific situations (e.g., location and default assumptions) in which they are used.
Bao, Jie, Braines, Dave, Mott, David, Smart, Paul R   +3 more
core  

A Research Agenda for Ending Homelessness [PDF]

, 2007
This Research Agenda was developed in order to better inform government agencies, philanthropic organizations, and other funders about research questions that will help move policy and practice forward.

core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Free will, temptation, and self-control: We must believe in free will, we have no choice (Isaac B. Singer). [PDF]

Baumeister, Sparks, Stillman, and Vohs (2007) sketch a theory of free will as the humanability to exert self-control. Self-control can produce goal-directed behavior, which free will conceptualized as random behavior cannot.
Bruyneel, Sabrina, Vosgerau, Joachim, Wertenbroch, Klaus   +2 more
core   +3 more sources

A scoping review of emotional contagion research with human subjects: identifying common trends of previous research and potential areas for future research

Frontiers in Psychology
IntroductionEmotional contagion (EC) involves the automatic mimicry and synchronization of expressions, vocalizations, and movements, resulting in emotional alignment between individuals.
Barret Michalec, Chad E. Forbes, Kevin Pardon, Bella Ayala, Diego Guevara Beltran, Clarice Douille, Kaitlyn Felix, Samantha Gnall, Michael Hoenack, Brooke McKeever, Daniel Nguyen, Nicole Piemonte, Sarah Portle   +12 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Conceptualization of grammatical facts

Polylinguality and Transcultural Practices, 2009
The article is devoted to problems of conceptualization of grammatical facts which are reflected national world outlook of Russian bearers. In the methods of teaching Russian as a foreign it is expediently introduce the lexical versatilities of universal
L S Kruchkova
doaj