Results 151 to 160 of about 2,725,308 (288)

Two-needle-holder endoscopic hand suturing for a mucosal defect after rectal endoscopic submucosal dissection. [PDF]

Endoscopy
Hayasaka J, Kawai Y, Iwasaki H, Ochiai Y, Yamato H, Koyama A, Hoteya S.   +6 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Direct detection of an asteroid's heliocentric deflection: The Didymos system after DART. [PDF]

Sci Adv
Makadia R, Chesley SR, Herald D, Farnocchia D, Chabot NL, Naidu SP, Rivkin AS, Siakas A, Souami D, Tanga P, Tsavdaridis S, Tsiganis K, Bouquillon S, Eggl S.   +13 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combining advanced submucosal technologies for a fibrotic tattooed colonic recurrence. [PDF]

Endoscopy
De Sire R, Capogreco A, Minini F, Massimi D, Hassan C, Maselli R, Repici A.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Building Rural Health Research Capacity Through Embedded Researchers and Ecosystem Development. [PDF]

Aust J Rural Health
Wong Shee A, Namara KM, Alston L, Binder M, Buccheri A, Demasson K, Field M, Kavanagh B, King O, Malakellis M, Russell S, Sayner AM, Schlicht K, Aras D, Versace VL.   +14 more
europepmc   +1 more source

Linguistic peculiarities of life conceptualization in english idioms [PDF]

, 2009
Poliova, Svitlana
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessment of characteristics and treatment patterns of adult patients with acquired aplastic anemia in Turkiye (PLANE-TR). [PDF]

Ann Hematol
Gunduz E, Ulas T, Ozkalemkas F, Toprak SK, Karakulak EA, Ar MC, Gulbas Z, Ozkocaman V, Aydogan M, Buyukasik Y, Cerme MDO, Mehtap O, Kucur D, Kaya E, Yavasoglu I, Besisik SK, Ersal T, Yuksel M, Hacioglu S, Hacibekiroglu T, Kaya A, Sakci E, Yuksel MK, Ozet G, Cagliyan GA, Hasanzade U, Salim O, Pepeler MS, Turgut M, Kurekci DD, Giden AO, Sener S, Calika S, Dal MS.   +33 more
europepmc   +1 more source