Results 81 to 90 of about 2,725,308 (288)
Conceptual engineering: Conceptual innovation via conceptual refinement
MetaphilosophyAbstractMona Simion and Christoph Kelp (2020) have recently challenged the traditional conceptual engineering project. They defend a reorientation of this project that moves away from correcting conceptual shortcomings and emphasizes conceptual innovation instead. Central to their proposal is the role played by etiological functions.
openaire +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The conceptualization of time and the constancy of the speed of light
, 2005 In this work we show that the null result of the Michelson-Morley experiment in vacuum is deeply connected with the notion of time. It can be deduced without any mathematics only from the assumption that all good clocks can be used to measure time with ...
de Abreu, Rodrigo, Guerra, Vasco
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Clarifying the Relationship Between Trichotillomania and Anxiety [PDF]
, 2017 Although research has consistently linked unidimensional anxiety with Trichotillomania (TTM) severity, the relationships between TTM severity and anxiety dimensions (e.g., cognitive and somatic anxiety) are unknown.
Alexander, Jennifer R. +7 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Relating ethical leadership with work engagement: How workplace spirituality mediates?
Cogent Business & Management, 2020 Throughout the 21st century, change has been a predominant theme in the workplace. Increased technology and globalization are two key contributors to the changing landscape.
Nosheen Adnan +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
RECREATIONAL ACTIVITIES AND NONMARKET VALUATION: THE CONCEPTUALIZATION ISSUE [PDF]
Resource /Energy Economics and Policy,
Stoll, John R.
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source