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Reconstitution and subunit geometry of human condensin complexes
EMBO Journal, 2007 Vertebrate cells possess two different condensin complexes, known as condensin I and condensin II, that play a fundamental role in chromosome assembly and segregation during mitosis.
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Condensin Regulation of Genome Architecture
Journal of Cellular Physiology, 2017Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied in mitosis but have recently emerged as important regulators of genome organization and gene ...
Vibhuti, Rana, Giovanni, Bosco
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Biochemical Analysis of Bacterial Condensins
2017Condensins help establish compactness of bacterial chromosomes and assist in their segregation during cell growth and division. They act as elaborate macromolecular machines that organize the chromosome on a global scale and link it to the pan-cell dynamics. The mechanism of condensins in its entirety is yet to be elucidated.
Zoya M, Petrushenko +1 more
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Capturing condensin in chromosomes
Nature Genetics, 2017A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.
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Condensin: Architect of mitotic chromosomes
Chromosome Research, 2009Condensin is a highly conserved pentameric complex consisting of two structural maintenance of chromosome (SMC) ATPase subunits and three auxiliary components. While initially regarded as a key driver of mitotic chromosome condensation, condensin is increasingly viewed as having a more subtle influence on chromosome architecture.
Damien F, Hudson +2 more
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Exploring Condensins with Magnetic Tweezers
2017The signature activity of condensins as DNA reshaping machines is their ability to impose the giant loop architecture onto the chromosome. At the heart of this activity lies the propensity of the proteins to assemble into macromolecular clusters that bring distant DNA segments together.
Rupa, Sarkar, Valentin V, Rybenkov
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Condensin, cohesin and the control of chromatin states
Current Opinion in Genetics & Development, 2013Cohesin and condensin complexes are essential for defining the topology of chromosomes through the cell cycle. Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology.
Aragon, L +2 more
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Mitotic chromosome formation and the condensin paradox
Experimental Cell Research, 2004During cell division, the chromatin is compacted and resolved into discrete mitotic chromosomes whose proper formation is essential for the faithful distribution of the replicated genome to the daughter cells. Chromatin within mitotic chromosomes is packaged in an orderly and reproducible fashion, but the nature of this higher-order structure has ...
Reto, Gassmann +3 more
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Clarifying the role of condensin in shaping chromosomes
Nature Cell Biology, 2015A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and ...
Kota, Nagasaka, Toru, Hirota
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