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Condensin, master organizer of the genome
Chromosome Research, 2017A fundamental requirement in nature is for a cell to correctly package and divide its replicated genome. Condensin is a mechanical multisubunit complex critical to this process. Condensin uses ATP to power conformational changes in DNA to enable to correct DNA compaction, organization, and segregation of DNA from the simplest bacteria to humans.
Paul, Kalitsis +4 more
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Condensin: Architect of mitotic chromosomes
Chromosome Research, 2009Condensin is a highly conserved pentameric complex consisting of two structural maintenance of chromosome (SMC) ATPase subunits and three auxiliary components. While initially regarded as a key driver of mitotic chromosome condensation, condensin is increasingly viewed as having a more subtle influence on chromosome architecture.
Damien F, Hudson +2 more
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Exploring Condensins with Magnetic Tweezers
2017The signature activity of condensins as DNA reshaping machines is their ability to impose the giant loop architecture onto the chromosome. At the heart of this activity lies the propensity of the proteins to assemble into macromolecular clusters that bring distant DNA segments together.
Rupa, Sarkar, Valentin V, Rybenkov
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Contrasting roles of condensin I and condensin II in mitotic chromosome formation
2013In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes. To dissect accurately the role of each complex in mitosis, we have made and studied the first vertebrate conditional knockouts of the genes encoding condensin I subunit CAP-H and condensin II subunit ...
Green, LC +12 more
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Condensin, cohesin and the control of chromatin states
Current Opinion in Genetics & Development, 2013Cohesin and condensin complexes are essential for defining the topology of chromosomes through the cell cycle. Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology.
Aragon, L +2 more
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Mitotic chromosome formation and the condensin paradox
Experimental Cell Research, 2004During cell division, the chromatin is compacted and resolved into discrete mitotic chromosomes whose proper formation is essential for the faithful distribution of the replicated genome to the daughter cells. Chromatin within mitotic chromosomes is packaged in an orderly and reproducible fashion, but the nature of this higher-order structure has ...
Reto, Gassmann +3 more
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Clarifying the role of condensin in shaping chromosomes
Nature Cell Biology, 2015A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and ...
Kota, Nagasaka, Toru, Hirota
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