Results 161 to 170 of about 7,152 (199)

Condensin chromatin association is regulated by SMC head and hinge engagement and phosphorylation

Miles CA, Yu M, Minchell NE, Schalbetter SA, Oliver AW, Sweet SM, Baxter J.   +6 more
europepmc   +1 more source

Investigations into fission yeast chromosome size determinants

Wu P, Fallesen T, Uhlmann F.
europepmc   +1 more source

Condensin II Activation by M18BP1 [PDF]

Molecular Cell
ABSTRACT Condensin complexes promote the drastic spatial rearrangement of the genome upon mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent chromosome condensation during interphase, condensin II is inhibited by MCPH1, but the mechanism is unknown.
Andrea Musacchio, Erin E Cutts, Judith H I Haarhuis   +2 more
exaly   +7 more sources

Differential Contributions of Condensin I and Condensin II to Mitotic Chromosome Architecture in Vertebrate Cells [PDF]

Cell, 2003
The canonical condensin complex (henceforth condensin I) plays an essential role in mitotic chromosome assembly and segregation from yeast to humans. We report here the identification of a second condensin complex (condensin II) from vertebrate cells.
Ana Losada, Andrew F Neuwald, Takao Ono
exaly   +5 more sources

Establishment of dsDNA-dsDNA Interactions by the Condensin Complex [PDF]

Molecular Cell, 2023
Condensin is a structural maintenance of chromosomes (SMC) complex family member thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants unable to extrude loops, yet proficient in chromosome formation, were recently ...
Juri Rappsilber, Hideki Tanizawa, Maxim I Molodtsov   +2 more
exaly   +6 more sources

Mitotic Chromatin Condensin' [PDF]

Nature Reviews Molecular Cell Biology, 2016
Eytan Zlotorynski
exaly   +2 more sources

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Condensin Regulation of Genome Architecture

Journal of Cellular Physiology, 2017
Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied in mitosis but have recently emerged as important regulators of genome organization and gene ...
Vibhuti, Rana, Giovanni, Bosco
openaire   +2 more sources

Condensin: crafting the chromosome landscape

Chromosoma, 2013
The successful transmission of complete genomes from mother to daughter cells during cell divisions requires the structural re-organization of chromosomes into individualized and compact structures that can be segregated by mitotic spindle microtubules. Multi-subunit protein complexes named condensins play a central part in this chromosome condensation
Ilaria, Piazza, Christian H, Haering, Anna, Rutkowska   +2 more
openaire   +2 more sources

Capturing condensin in chromosomes

Nature Genetics, 2017
A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.
openaire   +2 more sources

Biochemical Analysis of Bacterial Condensins

2017
Condensins help establish compactness of bacterial chromosomes and assist in their segregation during cell growth and division. They act as elaborate macromolecular machines that organize the chromosome on a global scale and link it to the pan-cell dynamics. The mechanism of condensins in its entirety is yet to be elucidated.
Zoya M, Petrushenko, Valentin V, Rybenkov   +1 more
openaire   +2 more sources