Results 141 to 150 of about 4,930 (171)

Capturing condensin in chromosomes

Nature Genetics, 2017
A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.
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Contrasting roles of condensin I and condensin II in mitotic chromosome formation.

Journal of cell science, 2013
In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes. To dissect accurately the role of each complex in mitosis, we have made and studied the first vertebrate conditional knockouts of the genes encoding condensin I subunit CAP-H and condensin II subunit ...
Lydia C, Green, Paul, Kalitsis, Tsz M, Chang, Miri, Cipetic, Ji Hun, Kim, Owen, Marshall, Lynne, Turnbull, Cynthia B, Whitchurch, Paola, Vagnarelli, Kumiko, Samejima, William C, Earnshaw, K H Andy, Choo, Damien F, Hudson   +12 more
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Condensin: Architect of mitotic chromosomes

Chromosome Research, 2009
Condensin is a highly conserved pentameric complex consisting of two structural maintenance of chromosome (SMC) ATPase subunits and three auxiliary components. While initially regarded as a key driver of mitotic chromosome condensation, condensin is increasingly viewed as having a more subtle influence on chromosome architecture.
Damien F, Hudson, Kathryn M, Marshall, William C, Earnshaw   +2 more
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Exploring Condensins with Magnetic Tweezers

2017
The signature activity of condensins as DNA reshaping machines is their ability to impose the giant loop architecture onto the chromosome. At the heart of this activity lies the propensity of the proteins to assemble into macromolecular clusters that bring distant DNA segments together.
Rupa, Sarkar, Valentin V, Rybenkov
openaire   +2 more sources

Condensin, cohesin and the control of chromatin states

Current Opinion in Genetics & Development, 2013
Cohesin and condensin complexes are essential for defining the topology of chromosomes through the cell cycle. Here we look at the emerging role of these complexes in regulating chromatin structure and gene expression and reflect on how these activities could be linked with chromosome topology.
Aragon, L, Martinez-Perez, E, Merkenschlager, M   +2 more
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Mitotic chromosome formation and the condensin paradox

Experimental Cell Research, 2004
During cell division, the chromatin is compacted and resolved into discrete mitotic chromosomes whose proper formation is essential for the faithful distribution of the replicated genome to the daughter cells. Chromatin within mitotic chromosomes is packaged in an orderly and reproducible fashion, but the nature of this higher-order structure has ...
Reto, Gassmann, Paola, Vagnarelli, Damien, Hudson, William C, Earnshaw   +3 more
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Clarifying the role of condensin in shaping chromosomes

Nature Cell Biology, 2015
A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and ...
Kota, Nagasaka, Toru, Hirota
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Condensin Engages Chromatin

ChemBioChem, 2011
Boryana, Petrova, Christian H, Haering
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Topoisomerases I and II facilitate condensin DC translocation to organize and repress X chromosomes in C. elegans

Molecular Cell, 2022
Sevinç Ercan, , Ana Karina González Morao   +2 more
exaly  

Establishment of dsDNA-dsDNA interactions by the condensin complex

Molecular Cell, 2023
Juri Rappsilber, Hideki Tanizawa, Maxim Molodtsov   +2 more
exaly