Results 141 to 150 of about 98,771 (295)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

A Causal Inference Methodology to Support Research on Osteopenia for Breast Cancer Patients

Applied Sciences
Breast cancer is the most common cancer in the world. With a 5-year survival rate of over 90% for patients at the early disease stages, the management of side-effects of breast cancer treatment has become a pressing issue.
Niki Kiriakidou, Aristotelis Ballas, Cristina Meliá Hernando, Anna Miralles, Teta Stamati, Dimosthenis Anagnostopoulos, Christos Diou   +6 more
doaj   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Marginal and Conditional Importance Measures from Machine Learning Models and Their Relationship with Conditional Average Treatment Effect

CoRR
Interpreting black-box machine learning models is challenging due to their strong dependence on data and inherently non-parametric nature. This paper reintroduces the concept of importance through "Marginal Variable Importance Metric" (MVIM), a model-agnostic measure of predictor importance based on the true conditional expectation function.
Mohammad Kaviul Anam Khan, Olli Saarela, Rafal Kustra   +2 more
openaire   +2 more sources

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Machine learning-based high-benefit approach versus traditional high-risk approach in statin therapy: the Shizuoka Kokuho database study

Scientific Reports
Statins are widely prescribed for the primary prevention of cardiovascular diseases, yet individual responses vary, necessitating personalized treatment strategies.
Ryo Watanabe, Eiji Nakatani, Hideaki Kaneda, Daito Funaki, Yohei Sobukawa, Yoshihiro Tanaka, Nagato Kuriyama, Masato Takeuchi, Akira Sugawara   +8 more
doaj   +1 more source

Erratum to: FoCAT: Foundation Model for Estimating the Conditional Average Treatment Effect

Doklady Mathematics
An Erratum to this paper has been published: https://doi.org/10.1134 ...
S. R. Kirpichenko, A. V. Konstantinov, L. V. Utkin   +2 more
openaire   +1 more source

The Causal Effect of Parents' Schooling on Children's Schooling - A Comparison of Estimation Methods [PDF]

We review the empirical literature that estimates the causal effect of parent’s schooling on child’s schooling, and conclude that estimates differ across studies.
Mikael Lindahl, Erik Plug, Helena Holmlund   +2 more
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