Results 121 to 130 of about 98,771 (295)

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Educational expansion and its heterogeneous returns for wage workers [PDF]

The paper examines the evolution of returns to education in the West German labour market over the last two decades. During this period, graduates from the period of educational expansion in the sixties and seventies entered the labour market and an ...
Gebel, Michael, Pfeiffer, Friedhelm
core   +2 more sources

Impact of conditional cash transfer on households food security in Akwa Ibom State, Nigeria.

PLoS ONE
The Nigerian government introduced the Household Upliftment Program (HUP) which is a conditional cash transfer scheme to help households improve consumption levels, reduce poverty and therefore prevent vulnerable households from becoming poorer.
Otu W Ibok, Iniobong E Okon, Oscar P Akpan, Imefon F Isip   +3 more
doaj   +1 more source

FoCAT: Foundation Model for Estimating the Conditional Average Treatment Effect

Doklady Mathematics
Abstract The paper presents a novel foundation model, FoCAT (Foundation Causal Adaptive Transformer), developed for estimating the conditional treatment effect. The model addresses several key challenges inherent in causal inference tasks, including a limited sample size in the treatment group, the impossibility
S. R. Kirpichenko, A. V. Konstantinov, L. V. Utkin   +2 more
openaire   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Active Labor Market Policy Effects in a Dynamic Setting [PDF]

This paper implements a method to identify and estimate treatment effects in a dynamic setting where treatments may occur at any point in time. By relating the standard matching approach to the timing-of-events approach, it demonstrates that effects of ...
Ferracci, Marc, Jolivet, Grégory, van den Berg, Gerard J., Crépon, Bruno   +3 more
core   +2 more sources

Elucidating the causal relationship of mechanical power and lung injury: a dynamic approach to ventilator management

Intensive Care Medicine Experimental
Background Mechanical power (MP) serves as a crucial predictive indicator for ventilator-induced lung injury and plays a pivotal role in tailoring the management of mechanical ventilation.
ChaoPing Wu, Arif Canakoglu, Jacob Vine, Anya Mathur, Ronit Nath, Markos Kashiouris, Piyush Mathur, Ari Ercole, Paul Elbers, Abhijit Duggal, Ken Koon Wong, Anirban Bhattacharyya   +11 more
doaj   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Conditional average treatment effect (CATE) of maternal education under conflict) blue = zero level of conflict, red = more than 10 on the conflict intensity scale.

, 2019
Conditional average treatment effect (CATE) of maternal education under conflict) blue = zero level of conflict, red = more than 10 on the conflict intensity scale.
Nadine Kraamwinkel (5018939), Adel Daoud (3173796), Stefania Davia (6191129), Hans Ekbrand (6191126)   +3 more
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source