Results 81 to 90 of about 384,025 (280)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Role of the necessity and sufficiency in the thematic material effect and perspective effect of the Wason selection task

Journal of Human Environmental Studies, 2006
This study examined whether necessity and sufficiency relations predict the thematic material effect and the perspective effect of the Wason selection task.
Hiroko Nakamura, Jun Kawaguchi
doaj   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

On Estimation of Genome Composition in Genetically Admixed Individuals Using Constrained Genomic Regression

Frontiers in Genetics, 2018
Quantifying the population stratification in genotype samples has become a standard procedure for data manipulation before conducting genome wide association studies, as well as for tracing patterns of migration in humans and animals, and for inference ...
Vinzent Boerner, Dörte Wittenburg
doaj   +1 more source

Approximate selective inference via maximum likelihood

, 2020
This article considers a conditional approach to selective inference via approximate maximum likelihood for data described by Gaussian models. There are two important considerations in adopting a post-selection inferential perspective.
Panigrahi, Snigdha, Taylor, Jonathan
core  

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

The Logical Dimension of Argumentation and Its Semantic Appraisal in Bermejo-Luque’s Giving Reasons

Theoria, 2011
We critically examine Bermejo-Luque’s account of the logical dimension of argumentation and its logical or semantic evaluation. Our considerations concern her views on inference claims, validity, logical normativity, warrants, necessity, warrants and the
James B. Freeman
doaj   +1 more source

Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring

Advanced Science, EarlyView.
This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen, Haoyu Wang, Guixin Xu, Yuqin Yuan, Xinmeng Cai, Zhengwu Wei, Dongheng Zhang, Qibin Sun, Tianwei Zhang, Cuntai Guan, Yan Chen   +10 more
wiley   +1 more source

Repulsive Guidance for Memorization Mitigation in Text-to-Music Diffusion Models

Mathematics
Recent progress in text-to-music generation has enabled high-quality audio synthesis from natural language prompts. However, such models are at risk of unintended replication, raising concerns regarding originality and intellectual property.
Taehyeon Kim, Hangyeol Lee, Chang Wook Ahn, Man-Je Kim   +3 more
doaj   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source