FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
The Hippocampus Is the Place to Be: Opioid Receptors and LTP
Cell Reports, 2019 Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson +3 more
doaj +1 more source
Oxytocin Attenuates Expression, but Not Acquisition, of Sucrose Conditioned Place Preference in Rats
Frontiers in Behavioral Neuroscience, 2020 Maladaptation of reward processing for natural rewards, such as sucrose or sugar, may play a role in the development of diseases such as obesity and diabetes.
Devon Patel +3 more
doaj +1 more source
Effects of brain insulin in conditioned place preference using exercise as a reward stimulus [PDF]
, 2017 Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs acadèmic: 2016/2017Researches suggest that physical activity is effective to prevent or treat stress-related psychiatric disorders such as depression, anxiety,
Espinosa-Fernández, Verónica
core
Effects of hunger state on flavour pleasantness conditioning at home: flavour-nutrient learning vs. flavour-flavour learning [PDF]
, 2007 This study examined acquired liking of flavour preferences through flavour-flavour and flavour-nutrient learning under hungry or sated conditions in a naturalistic setting.
Ackroff +54 more
core +1 more source
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
The influence of hot arid climate on the use of outdoor urban spaces and thermal comfort: do cultural and social backgrounds matter? [PDF]
, 2010 Climate-sensitive open spaces within cities may benefit the three dimensions of sustainability affecting economic, social and environmental factors. Aiming to improve microclimatic conditions in urban spaces can enable people to spend more time outdoors,
Aljawabra, Faisal +1 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Psychological types of female primary school teachers in Anglican state-maintained schools in England and Wales : implications for continuing professional development [PDF]
, 2011 A sample of 221 female primary school teachers in Anglican state-maintained schools in England and Wales completed the Francis Psychological Type Scales (FPTS).
Francis, Leslie J. +2 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source