Results 111 to 120 of about 197,171 (310)

Effects of palmitoylethanolamide in cocaine-induced behaviours [PDF]

, 2016
Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels of lipid-based signalling ...
Blanco, Eduardo, Castilla-Ortega, Estela, Galeano, Pablo, Ladrón de Guevara-Miranda, David, Rodríguez de Fonseca, Fernando, Rosell del Valle, Cristina, Santin-Nuñez, Luis Javier, Zambrana-Infantes, Emma   +7 more
core  

Formation of a morphine-conditioned place preference does not change the size of evoked potentials in the ventral hippocampus–nucleus accumbens projection [PDF]

, 2019
In opioid addiction, cues and contexts associated with drug reward can be powerful triggers for drug craving and relapse. The synapses linking ventral hippocampal outputs to medium spiny neurons of the accumbens may be key sites for the formation and ...
AB Mulder, AF MacAskill, AF MacAskill, AJ Gruber, AK Fakira, AR McQuiston, BA Strange, C Reakkamnuan, CM Pennartz, CR Yang, CS Lansink, DM Bannerman, EI Moser, ES Calipari, FA Bull, FH Lopes da Silva, GJ Mogenson, GS Portugal, HJ Groenewegen, HS Crombag, J Ferbinteanu, JF DeFrance, JM Bossert, JP Britt, JW Rudy, KJ Feasey-Truger, L Degenhardt, L Hoz de, L Hoz de, L Sjulson, LW Swanson, M Contreras, M Loureiro, MA Linseman, MA Meer van der, MA Meer van der, MC Hearing, MS Alvandi, NJ Marchant, P O’Donnell, PE Rothwell, PH Boeijinga, PH Boeijinga, PW German, R Ito, R Spanagel, RA Wise, RK McHugh, SJ French, SJ Martin, SJ Martin, SK Billa, SV Albertin, T Bast, TA LeGates, TE Robinson, V Pascoli, WL Isaac, Y Goto, Y Goto, Y Xia, Y Yang, Z Dong   +62 more
core   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice. [PDF]

, 2020
Methamphetamine (MA) and alcohol use disorders exhibit a high degree of co-morbidity and sequential alcohol-MA mixing increases risk for co-abuse. Recently, we reported greater MA-conditioned reward in male C57BL/6J mice with a prior history of binge ...
Bryant, Camron D, Coelho, Michal A, Fultz, Elissa K, Sern, Kimberly R, Szumlinski, Karen K   +4 more
core   +1 more source

Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference [PDF]

, 2013
Stress increases the risk of drug abuse, causes relapse to drug seeking, and potentiates the rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which stress regulates the rewarding properties of drugs of abuse provides ...
Al-Hasani, Ream, Bruchas, Michael R, McCall, Jordan G   +2 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats

Frontiers in Pharmacology
Background:Melatonin is responsible for regulating the sleep-wake cycle and circadian rhythms in mammals. Tramadol, a synthetic opioid analgesic, is used to manage moderate to severe pain but has a high potential for abuse and dependence.
Alqassem Y. Hakami, Alqassem Y. Hakami, Badrah S. Alghamdi, Badrah S. Alghamdi, Fahad S. Alshehri   +4 more
doaj   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
core   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source