Results 51 to 60 of about 1,465,876 (250)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging [PDF]
, 1999 Previous functional neuroimaging studies have characterized brain systems mediating associative learning using classical delay conditioning paradigms.
Buchel, C +7 more
core
Programmable responsive hydrogels inspired by classical conditioning algorithm
Nature Communications, 2019 Living systems inspired research on systems chemistry to mimic specific complex biological functions, but mimicking even the most elementary aspects of learning is a grand challenge. Here the authors demonstrate a programmable hydrogel-based model system,
Hang Zhang +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Olfactory classical PER conditioning protocol.
, 2022 Experimental procedure of paired group olfactory classical PER conditioning (inspired by Matsumoto et al. 2012). Lavender (conditioning stimulus, CS) was applied for 5s. After 3s, sucrose 50% (unconditioning stimulus, US) was presented. Each bee received
Jacques Lebreton (602836) +5 more
core +1 more source
Classical Fear Conditioning in Turtles (Chrysemys picta)
International Journal of Comparative PsychologyIn all organisms, fear conditioning is a behavior that would be expected to be adaptive for anticipating dangerous stimuli. It therefore should have been selected for in the course of evolution.
Christopher Lau +7 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Learning to like disgust: Neuronal correlates of counterconditioning
Frontiers in Human Neuroscience, 2013 Converging lines of research suggest that exaggerated disgust responses play a crucial role in the development and maintenance of certain anxiety disorders. One strategy that might effectively alter disgust responses is counterconditioning. In this study,
Jan eSchweckendiek +8 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source