Results 61 to 70 of about 1,465,876 (250)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2006 A learning object produced for the X4L Colossus Project. It discusses Pavlov's discovery of classical conditioning when working in his laboratory, and its influence on the development of behaviourist psychology.
Sharon Boyd
core
Editorial: Higher-Order Conditioning: Beyond Classical Conditioning
Frontiers in Behavioral Neuroscience, 2022 Arnau Busquets-Garcia, Nathan M. Holmes
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The Role of Behaviourist Theory in Educational Technology [PDF]
دراسات تربوية و نفسية - مجلة كلية التربية بالزقازيقEducators from behaviourist theory’s perspective can shape the behaviour and responses of learners to a specific stimulus in order to help them acquire new knowledge.. Research has been performed, previously, into how students learn and gain information,
doaj +1 more source
Mismatch Negativity in Rat Auditory Cortex Represents the Empirical Salience of Sounds
Frontiers in Neuroscience, 2018 Mismatch negativity (MMN) is an N-methyl-D-aspartic acid-mediated component and thus has been widely considered a major candidate biomarker of schizophrenia.
Tomoyo Isoguchi Shiramatsu +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Implementing classical conditioning with spiking neurons
, 2007 In this paper, we attempt to implement classical conditioning with spiking neurons instead of connectionist neural networks. The neuron model used is a leaky linear integrate-and-fire model with a learning algorithm combining spike-time dependent Hebbian
Liu, Chong +3 more
core +1 more source
Computational Models of Classical Conditioning: A Qualitative Evaluation and Comparison [PDF]
, 2014 Classical conditioning is a fundamental paradigm in the study of learning and thus in understanding cognitive processes and behaviour, for which we need comprehensive and accurate models.
Alonso, E., Mondragon, E., Sahota, P.
core +4 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source