Results 101 to 110 of about 120,420 (290)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Condition numbers and equilibration of matrices
Numerische Mathematik, 1969 Introduction In numerical linear algebra one meets condition numbers [[AII []A-11[ and similar quantities such as (max [a,i[)[[A-1H and [[Ai[[ [[A-l[], where A = (a,i) and A i is the /'-th column of A. The norms are very diverse. The problem then is to determine a rowand/or column-scaling of A which minimizes the quanti ty under consideration.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
GelsThe escalating demand for global fruit logistics underscores the urgency of packaging innovations to reconcile preservation efficiency with environmental sustainability, particularly addressing microplastic pollution from conventional plastics and safety
Tong Zhao +8 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fast estimation of Kendall's Tau and conditional Kendall's Tau matrices under structural assumptions
Dependence ModelingKendall’s tau and conditional Kendall’s tau matrices are multivariate (conditional) dependence measures between the components of a random vector. For large dimensions, available estimators are computationally expensive and can be improved by averaging ...
van der Spek Rutger, Derumigny Alexis
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Structural characterization of uranium and lanthanide loaded borosilicate glass matrix
Scientific ReportsBorosilicate glass is a potential candidate for high-level radioactive waste conditioning, thus understanding the effects caused by the combined presence of uranium and actinides within these matrices is of great importance.
I. Tolnai +5 more
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Inversion of extremely Ill-conditioned matrices in floating-point [PDF]
Japan Journal of Industrial and Applied Mathematics, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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