Results 91 to 100 of about 41,990 (343)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Eigenvalues and Condition Numbers of Random Matrices [PDF]
SIAM Journal on Matrix Analysis and Applications, 1988 Let X be a random matrix whose entries are independent standard normal random variables. Denote by \(\kappa =\| X\| \| X^{-1}\|\) its condition number in the 2-norm. The author presents a proof that for real \(n\times n\) matrices \(E(\log \kappa)\approx \log n+1.537\) and for complex matrices \(E(\log \kappa)\approx \log n+0.982\) as \(n\to \infty ...
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
GelsThe escalating demand for global fruit logistics underscores the urgency of packaging innovations to reconcile preservation efficiency with environmental sustainability, particularly addressing microplastic pollution from conventional plastics and safety
Tong Zhao +8 more
doaj +1 more source
On diagonal representatives in boundary condition matrices on orbifolds [PDF]
, 2020 Yoshiharu Kawamura, Yasunari Nishikawa
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fast estimation of Kendall's Tau and conditional Kendall's Tau matrices under structural assumptions
Dependence ModelingKendall’s tau and conditional Kendall’s tau matrices are multivariate (conditional) dependence measures between the components of a random vector. For large dimensions, available estimators are computationally expensive and can be improved by averaging ...
van der Spek Rutger, Derumigny Alexis
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Structural characterization of uranium and lanthanide loaded borosilicate glass matrix
Scientific ReportsBorosilicate glass is a potential candidate for high-level radioactive waste conditioning, thus understanding the effects caused by the combined presence of uranium and actinides within these matrices is of great importance.
I. Tolnai +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source