Results 81 to 90 of about 251 (211)

Structural characterization of uranium and lanthanide loaded borosilicate glass matrix

Scientific Reports
Borosilicate glass is a potential candidate for high-level radioactive waste conditioning, thus understanding the effects caused by the combined presence of uranium and actinides within these matrices is of great importance.
I. Tolnai, J. Osan, P. Jovari, F. Pinakidou, A. Sulyok, M. Fabian   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development and Characterization of Honey- and Essential Oil-Based Structured Systems for Skin Applications

Pharmaceuticals
Background: The present study aimed to develop and characterize three honey- and essential oil-based structured systems intended for topical skin application. Materials and Methods: The semisolid systems were prepared as oil-in-water structured emulsions
Corina-Bianca Ioniță-Mîndrican, Manuela Ghica, Ancuța Cătălina Fița, Eliza Oprea, Mihaela Buleandră, Irinel Adriana Badea, Cristina-Ionela Stănciulescu, Emma Adriana Ozon, Silviu-Iulian Filipiuc, Carolina Negrei   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Invertibility Conditions for Block Matrices and Estimates for Norms of Inverse Matrices

Rocky Mountain Journal of Mathematics, 2003
The author derives a non-sigularity criterion for block matrices. Invertibility conditions which improve well-known results for matrices that are ``close'' to block triangular matrices are proposed. Finally an estimate for the norm of the inverse matrices is derived.
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A responsive integrated dry route for uranium hexafluoride conversion using machine intelligence

Energy Conversion and Management: X
A modification of the integrated dry route (IDR) process for uranium conversion in nuclear fuel fabrication to render it responsive to react and adapt to changes in measured variables is described.
Manuel Bandala, Patrick Chard, Neil Cockbain, David Dunphy, David Eaves, Daniel Hutchinson, Darren Lee, Gareth Leech, Xiandong Ma, Stephen Marshall, Paul Murray, Andrew Parker, Paul Stirzaker, C. James Taylor, Jaime Zabalza, Malcolm J. Joyce   +15 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Non-continuous Percoll density gradient: a method for purifying Mycobacterium tuberculosis from dust

BMC Infectious Diseases
Background Mycobacterium tuberculosis (MTB) retains infectivity for 8–10 days in dry dust and survives up to 6–8 months in humid environments. Dust accumulated in ventilation systems and air-conditioning filters serves as a critical reservoir for MTB ...
Lan Wen, Wei Ning, Hui-ping Zhang, Fang Peng, Miao-miao Wang, Fei-fan Huang, Bin Zhang, Jie-peng Huang, Ming-zhong Xu, Bin Tian   +9 more
doaj   +1 more source