Results 61 to 70 of about 120,420 (290)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Effective Variational Data Assimilation in Air-Pollution Prediction
Big Data Mining and Analytics, 2018 Numerical simulations are widely used as a predictive tool to better understand complex air flows and pollution transport on the scale of individual buildings, city blocks, and entire cities.
Rossella Arcucci +2 more
doaj +1 more source
Condition numbers of random matrices
Journal of Complexity, 1991 The author derives upper and lower bounds differing by a constant multiple for the expectation of the condition number of random \(n\times n\) matrices in the \(L_ p\) norm. These bounds have been independently obtained by \textit{A. Edelman} [SIAM J. Matrix Anal. Appl. 9, No. 4, 543-560 (1988; Zbl 0678.15019)] and \textit{E.
openaire +1 more source
A Subspace Shift Technique for Nonsymmetric Algebraic Riccati Equations
, 2011 The worst situation in computing the minimal nonnegative solution of a nonsymmetric algebraic Riccati equation associated with an M-matrix occurs when the corresponding linearizing matrix has two very small eigenvalues, one with positive and one with ...
Berman +21 more
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Energies, 2021 This article presents the analysis of the convergence of energy use from renewable sources among chosen European countries using a spatio-temporal approach.
Mateusz Jankiewicz
doaj +1 more source
Spectral Condition Numbers of Orthogonal Projections and Full Rank Linear Least Squares Residuals
, 2010 A simple formula is proved to be a tight estimate for the condition number of the full rank linear least squares residual with respect to the matrix of least squares coefficients and scaled 2-norms.
Grcar, Joseph F.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Applied SciencesShale reservoirs provide critical storage space for unconventional oil and gas, yet their frequent vertical facies alternations and complex spatial architectures make it difficult for conventional two-point geostatistical methods to reproduce thin ...
Maozhou Han +6 more
doaj +1 more source
Fire, 2023 Wildfires are one of the gravest and most momentous hazards affecting rich forest biomes worldwide; India is one of the hotspots due to its diverse forest types and human-induced reasons.
Aishwarya Sinha +14 more
doaj +1 more source