Results 11 to 20 of about 434,913 (295)

Blinatumomab added to conditioning regimen of allogeneic hematopoietic stem cell transplantation for adult MRD-positive acute lymphoblastic leukemia: a single-center case series

Hematology
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the mainstay of treatment for adults with high-risk acute lymphoblastic leukemia (ALL).
Hui Fu, Yanmin Zhao, Huarui Fu, Meng Liu, Congxiao Zhang, Li Yang, He Huang, Jimin Shi, Jian Yu   +8 more
doaj   +2 more sources

TREOSULFAN-BASED CONDITIONING REGIMEN IN SIBLING AND ALTERNATIVE DONOR HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CHILDREN WITH SICKLE CELL DISEASE [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background and objectives  Lack of suitable donors and regimen related toxicity are major barriers for hematopoietic stem cell transplantation (HSCT) in patients with sickle cell disease (SCD) when employing the most frequently used Busulfan-based ...
Antonio Marzollo, Elisabetta Calore, Manuela Tumino, Marta Pillon, Maria Vittoria Gazzola, Roberta Destro, Raffaella Colombatti, Piero Marson, Tiziana Tison, Anna Colpo, Chiara Mainardi, Maria Gabelli, Maria Paola Boaro, Sara Rossin, Aurora Strano, Nadia Quaglia, Federica Menzato, Giuseppe Basso, Laura Sainati, Chiara Messina   +19 more
doaj   +2 more sources

Successful allogeneic bone marrow transplantation using immunosuppressive conditioning regimen for a patient with red blood cell transfusion-dependent pyruvate kinase deficiency anemia

Hematology Reports, 2020
Pyruvate kinase deficiency (PKD) is the rare glycolytic enzyme defect causing hemolytic anemia. Treatments are mainly red cell transfusion and/or splenectomy, leading to iron overload.
Maiko Shimomura, Takehiko Doi, Shiho Nishimura, Yusuke Imanaka, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi, Masao Kobayashi   +7 more
doaj   +2 more sources

Fludarabine/Cyclophosphamide Conditioning Regimen in Aplastic Anemia Patients Receiving Matched-Sibling Donor Transplant Is Non-inferior to ATG/Cyclophosphamide: A Single-Center Experience from Pakistan

Stem Cells International, 2022
The successful outcome of allogeneic hematopoietic stem cell transplant (HSCT) in aplastic anemia patients is driven by suitable donor selection, appropriate conditioning regimen, early intervention, and optimal supportive care after transplant. Pakistan,
Uzma Zaidi, Mushkbar Fatima, Shafaq Abdul Samad, Kashif Shafique, Hira Fatima Waseem, Tasneem Farzana, Tahir Sultan Shamsi   +6 more
doaj   +2 more sources

Lymphodepleting Conditioning Regimens [PDF]

, 2022
AbstractLymphodepleting conditioning regimens are essential for the success of CAR-T cell treatment. Their importance in the proliferation and persistence of CAR-T cells has become clearer in the recent years. The suggested mechanisms are described in Table 25.1 and include the effects on immune cells and cytokines, creating an environment for optimal ...
Mohamad Mohty, Monique C. Minnema
openaire   +1 more source

Decitabine-Intensified Modified Busulfan/Cyclophosphamide Conditioning Regimen Improves Survival in Acute Myeloid Leukemia Patients Undergoing Related Donor Hematopoietic Stem Cell Transplantation: A Propensity Score Matched Analysis

Frontiers in Oncology, 2022
To identify the benefit of decitabine (Dec)-intensified myeloablative conditioning on the outcomes of patients with acute myeloid leukemia (AML) after related donor hematopoietic stem cell transplantation (HSCT), we performed a retrospective matched‐pair
Ziying Li, Wei Shi, Xuan Lu, Hui Lu, Xiena Cao, Liang Tang, Han Yan, Zhaodong Zhong, Yong You, Linghui Xia, Yu Hu, Huafang Wang   +11 more
doaj   +1 more source

Therapeutic Drug Monitoring of Conditioning Agents in Pediatric Allogeneic Stem Cell Transplantation; Where do We Stand?

Frontiers in Pharmacology, 2022
Allogeneic hematopoietic stem cell transplantation (HSCT) is an established curative treatment that has significantly improved clinical outcome of pediatric patients with malignant and non-malignant disorders.
M. Y. Eileen C. van der Stoep, Lisa V. E. Oostenbrink, Robbert G. M. Bredius, Dirk Jan A. R. Moes, Henk-Jan Guchelaar, Juliette Zwaveling, Arjan C. Lankester   +6 more
doaj   +1 more source

Personalized prediction of overall survival in patients with AML in non‐complete remission undergoing allo‐HCT

Cancer Medicine, 2021
Allogenic hematopoietic stem cell transplantation (allo‐HCT) is the standard treatment for acute myeloid leukemia (AML) in non‐complete remission (non‐CR); however, the prognosis is inconsistent.
Shigeki Hirabayashi, Ryuji Uozumi, Tadakazu Kondo, Yasuyuki Arai, Takahito Kawata, Naoyuki Uchida, Atsushi Marumo, Kazuhiro Ikegame, Takahiro Fukuda, Tetsuya Eto, Masatsugu Tanaka, Atsushi Wake, Junya Kanda, Takafumi Kimura, Ken Tabuchi, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada, Shingo Yano   +18 more
doaj   +1 more source

Experiences of allogeneic hematopoietic cell transplantation following non-myeloablative conditioning regimen in severely comorbid patients with myelofibrosis: case series with a patient presenting with extensive extramedullary hematopoiesis

Therapeutic Advances in Hematology, 2020
We have performed allogeneic hematopoietic cell transplantation (allo-HCT) using a reduced intensity conditioning regimen for curative management of advanced myelofibrosis (MF).
Jae-Ho Yoon, Sung-Soo Park, Gi June Min, Silvia Park, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Ki-Seong Eom   +12 more
doaj   +1 more source

Safety and efficacy of a modified busulfan/cyclophosphamide conditioning regimen incorporating cladribine for autologous hematopoietic stem cell transplantation in acute myeloid leukemia

Frontiers in Pharmacology, 2023
This is a small phase I study examining the safety and efficacy of a cladribine (CLAD)-containing conditioning regimen prior to autologous hematopoietic stem cell transplantion (auto-HSCT) for patients with acute myeloid leukemia (AML).
Yuan-Yuan Shi, Zeng-Yan Liu, Gui-Xin Zhang, Yi He, Ming-Zhe Han, Si-Zhou Feng, Rong-Li Zhang, Er-Lie Jiang   +7 more
doaj   +1 more source