Results 191 to 200 of about 5,046 (227)

Structural characterisation of defensive cone snail venom peptides

Toxicon, 2019
David T. Wilson, P. Bansal, S. Dutertre, N. Daly   +3 more
semanticscholar   +2 more sources

Therapeutic potential of cone snail venom peptides (conopeptides).

Current Topics in Medicinal Chemistry, 2012
Cone snails have evolved many 1000s of small, structurally stable venom peptides (conopeptides) for prey capture and defense. Whilst < 0.1% have been pharmacologically characterised, those with known function typically target membrane proteins of therapeutic importance, including ion channels, transporters and GPCRs. Several conopeptides reduce pain in
I. Vetter, R. Lewis
semanticscholar   +4 more sources

Ichthyotoxicity caused by marine cone snail venoms?

Toxicon, 2005
Ten venoms from marine cone snails were tested for ichthyotoxic effects on zebra fish (Brachydanio rerio) when added to the water. Only two venoms, from Conus capitaneus and Conus episcopatus, produced lethal effects at high concentrations (50-300 microg/ml) within 20-90 min. No sedative or hypnotic symptoms were observed.
Dietrich, Mebs, Silke, Kauferstein
openaire   +2 more sources

Cone Snail Venom Peptides and Future Biomedical Applications of Natural Products

, 2017
D. Newman, G. Cragg, P. Grothaus
semanticscholar   +3 more sources

Cone Snail Venomics: From Novel Biology to Novel Therapeutics

Future Medicinal Chemistry, 2014
Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review,
Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien, Lewis, Richard J.   +5 more
openaire   +3 more sources

7. The messiness of cone snail venom evolution

Toxicon, 2014
S. Dutertre
semanticscholar   +2 more sources

Neurotoxins of Cone Snail Venoms

2002
Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
openaire   +1 more source

Origins and evolution of cone snail venom systems

, 2023
Aymeric Rogalski
semanticscholar   +2 more sources

Venomic study on cone snails (Conus spp.) from South Africa

Toxicon, 2011
From six Conus species (Conus coronatus, Conus lividus, Conus mozambicus f. lautus, Conus pictus, Conus sazanka, Conus tinianus) collected off the eastern coast of South Africa the venoms were analyzed using MALDI-TOF mass spectrometry. Between 56 and 151 molecular masses most in a range of 1000 to 2500 Da, were identified.
Kauferstein, S., Porth, C., Kendel, Y., Wunder, C., Nicke, A., Kordis, D., Favreau, P., Koua, D., Stoecklin, R., Mebs, D.   +9 more
openaire   +3 more sources

Structural and biosynthetic properties of peptides in cone snail venoms

Peptides, 1995
Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
R, Newcomb, S, Gaur, J R, Bell, L, Cruz
openaire   +2 more sources