Results 201 to 210 of about 5,046 (227)

Pharmacology of predatory and defensive venom peptides in cone snails

Molecular BioSystems, 2017
Cone snails use distinct venoms for defence and prey capture. The pharmacology of these neurotoxic peptides have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics.
Jutty Rajan Prashanth, Sebastien Dutertre, Richard James Lewis   +2 more
openaire   +3 more sources

Phyla Molluska: The Venom Apparatus of Cone Snails

2015
Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien, Griffin, John, Lewis, Richard J.   +2 more
openaire   +2 more sources

Venomous cone snails: molecular phylogeny and the generation of toxin diversity

Toxicon, 2001
In order to investigate the generation of conotoxin diversity, delta-conotoxin sequences from nine Conus species were analyzed in the context of their phylogeny. Using a standard molecular marker, mitochondrial 16S RNA, we determined that the delta-conotoxins were derived from three distinct species clades based on the phylogenetic reconstruction of a ...
D J, Espiritu, M, Watkins, V, Dia-Monje, G E, Cartier, L J, Cruz, B M, Olivera   +5 more
openaire   +2 more sources

Cone snail prolyl-4-hydroxylase α-subunit sequences derived from transcriptomic data and mass spectrometric analysis of variable proline hydroxylation in C. amadis venom.

Journal of Proteomics, 2019
Putative prolyl-4-hydroxylase (P4H) α-subunit sequences have been extracted by mining transcriptomic data obtained from seven cone snail species C. amadis, C. monile, C. araneosus, C. miles, C. litteratus, C. frigidus, and C. ebraeus.
M. Vijayasarathy, P. Balaram
semanticscholar   +1 more source

Combinatorial peptide libraries in drug design: lessons from venomous cone snails

Trends in Biotechnology, 1995
Many present-day drugs are derived from compounds that are natural products, a traditional source of which is fermentation broths of microorganisms. The venoms of cone snails are a new natural resource of peptides that may have a pharmaceutical potential equivalent to those from traditional sources, particularly for developing drugs that target cell ...
B M, Olivera, D R, Hillyard, M, Marsh, D, Yoshikami   +3 more
openaire   +2 more sources

Proteome based de novo sequencing of novel conotoxins from marine molluscivorous cone snail Conus amadis and neurological activities of its natural venom in zebrafish model.

Protein Peptide Letters, 2019
Conus amadis is a carnivorous snail found abundantly in coastal waters of India. They are equipped with potent chemical arsenal made of neurotoxic peptide concoction used for predation and competition.
R. Rajesh, J. B. Franklin, Iffath Badsha, P. Arjun, R. Jain, M. Vignesh, R. Kannan   +6 more
semanticscholar   +1 more source

Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2011
A combination of proteomic and biochemical assays was used to examine variations in the venom of Conus vexillum taken from two locations (Hurgada and Sharm El-Shaikh) in the Red Sea, Egypt. Using MALDI/TOF-MS, a remarkable degree of intra-species variation between venom samples from both locations was identified.
Mohamed A, Abdel-Rahman, Ismail M, Abdel-Nabi, Mohamed S, El-Naggar, Osama A, Abbas, Peter N, Strong   +4 more
openaire   +2 more sources

Cone Snail Broad-Transcriptomics Elucidate the Evolutionary Diversification and Anti-Microbial Potential of Conopeptides

Journal of Marine Science and Engineering
Conus venoms are both highly powerful and complex, exhibiting a remarkably intriguing molecular variability. The biologic reasons behind such astonishing molecular diversity are yet to be fully understood.
José Morim, Yihe Zhao, Lei Huang, Agostinho Antunes   +3 more
semanticscholar   +1 more source

Ion Channel Toxins and Therapeutics: From Cone Snail Venoms to Ciguatera

Therapeutic Drug Monitoring, 2000
Ion channels are intimately linked to all neurotransmission and neurotransmitter release processes, but in disease states often contribute adversely to disease pathology. The diversity and distribution of ion channel types and subtypes being uncovered through the use of molecular biology and toxin probes present an exciting opportunity for the ...
openaire   +3 more sources

Overlooked dangers of cone snail venom: a neglected marine health risk

Ethics Medicine and Public Health
V. Romero, D.E. Lucero-Prisno, E. T. Romero   +2 more
semanticscholar   +1 more source