Results 71 to 80 of about 167,464,841 (288)
Cosmological singularities in brane gravity
Nuclear Physics BWe present a comprehensive study of cosmological singularities within the framework of Covariant Extrinsic Gravity (CEG), addressing both the initial Big Bang singularity and potential finite-time future singularities.
R. Jalalzadeh +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Geometric and algebraic classification of quadratic differential systems with invariant hyperbolas
Electronic Journal of Differential Equations, 2017 Let QSH be the whole class of non-degenerate planar quadratic differential systems possessing at least one invariant hyperbola. We classify this family of systems, modulo the action of the group of real affine transformations and time rescaling ...
Regilene D. S. Oliveira +3 more
doaj
Sections, multisections, and U(1) fields in F-theory
, 2019 © 2016, Journal of Singularities. All rights reserved. We show that genus-one fibrations lacking a global section fit naturally into the geometric moduli space of Weierstrass models. Elliptic fibrations with multiple sections (nonzero Mordell-Weil rank),
Taylor IV, Washington +3 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Historia Crítica, 2017 This article studies the process of the configuration of census statistics in the first half of the 20th century in Colombia. It indicates the singularities of the production and uses of these figures, and describes the problems that the Colombian state ...
Victoria Estrada Orrego
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
New Journal of Physics, 2012 We theoretically explore the optical flux lattices produced for ultra-cold atoms subject to laser fields where both the atom–light coupling and the effective detuning are spatially periodic. We analyze the geometric vector potential and the magnetic flux
G Juzeliūnas, I B Spielman
doaj +1 more source