Results 41 to 50 of about 720,373 (345)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Ex Vivo Fluorescein-Assisted Confocal Laser Endomicroscopy (CONVIVO® System) in Patients With Glioblastoma: Results From a Prospective Study

Frontiers in Oncology, 2020
BackgroundConfocal laser endomicroscopy (CLE) allowing intraoperative near real-time high-resolution cellular visualization is a promising method in neurosurgery.
Francesco Acerbi, Bianca Pollo, Camilla De Laurentis, Francesco Restelli, Jacopo Falco, Ignazio G. Vetrano, Morgan Broggi, Marco Schiariti, Irene Tramacere, Paolo Ferroli, Francesco DiMeco, Francesco DiMeco   +11 more
doaj   +1 more source

Characterization of the far-red fluorescent probe MitoView 633 for dynamic mitochondrial membrane potential measurement

Frontiers in Physiology, 2023
Introduction: MitoView 633, a far-red fluorescent dye, exhibits the ability to accumulate within mitochondria in a membrane potential-dependent manner, as described by the Nernst equation.
Patrick Ernst, Seulhee Kim, Zengqiao Yang, Xiaoguang Margaret Liu, Lufang Zhou, Lufang Zhou, Lufang Zhou   +6 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Time-Domain Full-Field Confocal Optical Coherence Tomography with Digital Scanning

Photonics
Full-field optical coherence tomography (FF-OCT) is a fast, en face interferometric technique that allows imaging inside a scattering tissue with high spatial resolution.
Danielis Rutkauskas, Karolis Adomavičius, Egidijus Auksorius   +2 more
doaj   +1 more source

Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.

Cochrane Database of Systematic Reviews, 2018
BACKGROUND Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Early detection and treatment is key to improving survival;
J. Dinnes, J. Deeks, D. Saleh, N. Chuchu, S. Bayliss, L. Patel, C. Davenport, Y. Takwoingi, Kathie Godfrey, R. Matin, R. Patalay, H. Williams   +11 more
semanticscholar   +1 more source

Digital confocal microscopy through a multimode fiber [PDF]

SPIE Organic Photonics + Electronics, 2015
Confocal laser-scanning microscopy is a well-known optical imaging method where a pinhole is used in the illumination and detection pathways of a normal microscope, in order to selectively excite and detect a particular focal volume.
D. Loterie, S. Farahi, I. Papadopoulos, A. Goy, D. Psaltis, C. Moser   +5 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Virtual Histology Staining of Skin Tissue using Ex Vivo Confocal Microscopy and Deep Learning [PDF]

Journal of Biomedical Physics and Engineering
Background: The use of Hematoxylin-and-Eosin (H&E) staining is widely accepted as the most reliable method for diagnosing pathological tissues. However, the conventional H&E staining process for tissue sections is time-consuming and requires significant ...
Mahmoud Bagheri, Alireza Ghanadan, Mobin Saboohi, Maryam Daneshpazhooh, Fatemeh Atyabi, Marjaneh Hejazi   +5 more
doaj   +1 more source