Results 51 to 60 of about 739,261 (262)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Efficacy of Chelating Agents on Calcium Hydroxide Removal from the Root Canals and their Influence on the Penetration of a Bioceramic Sealer: An In-vitro Evaluation [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Eliminating Calcium Hydroxide {Ca(OH)2 } remnants from root canal walls presents a significant challenge. Nevertheless, its complete removal enhances the deeper penetration of a sealer, which improves the three-dimensional (3D ...
Devika Chinnam, Ravi Chandra Ravi, Jyothi Mandava, Ravikumar Konagala, Sruthi Kapu, Ch Varaha Venkata Narasimha Raju   +5 more
doaj   +1 more source

Ex Vivo Fluorescein-Assisted Confocal Laser Endomicroscopy (CONVIVO® System) in Patients With Glioblastoma: Results From a Prospective Study

Frontiers in Oncology, 2020
BackgroundConfocal laser endomicroscopy (CLE) allowing intraoperative near real-time high-resolution cellular visualization is a promising method in neurosurgery.
Francesco Acerbi, Bianca Pollo, Camilla De Laurentis, Francesco Restelli, Jacopo Falco, Ignazio G. Vetrano, Morgan Broggi, Marco Schiariti, Irene Tramacere, Paolo Ferroli, Francesco DiMeco, Francesco DiMeco   +11 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

3D Confocal Microscopy

, 2022
Organization of organoid models imaged in 3D with confocal ...
Garrett Winkelmaier
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Progress in Confocal Laser Endomicroscopy for Neurosurgery and Technical Nuances for Brain Tumor Imaging With Fluorescein

Frontiers in Oncology, 2019
Background: Previous studies showed that confocal laser endomicroscopy (CLE) images of brain tumors acquired by a first-generation (Gen1) CLE system using fluorescein sodium (FNa) contrast yielded a diagnostic accuracy similar to frozen surgical sections
Evgenii Belykh, Evgenii Belykh, Eric J. Miller, Alessandro Carotenuto, Arpan A. Patel, Claudio Cavallo, Nikolay L. Martirosyan, Debbie R. Healey, Vadim A. Byvaltsev, Adrienne C. Scheck, Michael T. Lawton, Jennifer M. Eschbacher, Peter Nakaji, Mark C. Preul   +13 more
doaj   +1 more source

Experimental Analysis on Effectiveness of Confocal Algorithm for Radar Based Breast Cancer Detection [PDF]

, 2012
Breast cancer is one of the most commonly diagnosed cancers in females in UK [1]. Early breast cancer detection which has recently been gaining a lot of consideration within the research community and the most important for a quick and effective ...
ABDUL-SATTAR, ZUBAIDA
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Metalens-Based Miniaturized Optical Systems

Micromachines, 2019
Metasurfaces have been studied and widely applied to optical systems. A metasurface-based flat lens (metalens) holds promise in wave-front engineering for multiple applications.
Bo Li, Wibool Piyawattanametha, Zhen Qiu
doaj   +1 more source