Results 101 to 110 of about 3,678,372 (337)

Nonlinearity-induced conformational instability and dynamics of biopolymers

, 2001
We propose a simple phenomenological model for describing the conformational dynamics of biopolymers via the nonlinearity-induced buckling and collapse (i.e. coiling up) instabilities.
, , , Archilla J. F. R., Caspi S., Christiansen P. L., Davydov A. S., Doi M., Kuznetsov S. V., P. L Christiansen, Peyrard M., Peyrard M. (ed), Reigada R., S. F Mingaleev, Scott A. C., Taylor W. R., Y. B Gaididei, Y. S Kivshar, Yakushevich L. V.   +18 more
core   +1 more source

Conformational Dynamics in Neuroglobin [PDF]

Biophysical Journal, 2011
Neuroglobin (Ngb) is a heme protein that belongs to the family of hexacoordinated hemoglobins. The physiological role of this protein is not well understood, but several plausible functions have been proposed such as oxygen carrier, oxygen sensor, NO scavenger and protectant against oxidative damage. To understand the mechanism of Ngb interactions with
Astudillo, Luisana, Bernard, Sophie, Derrien, Valerie, Sebban, Pierre, Miksovska, Jaroslava   +4 more
openaire   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Identification of AtHsp90.6 involved in early embryogenesis and its structure prediction by molecular dynamics simulations [PDF]

Royal Society Open Science, 2019
Heat-shock protein of 90 kDa (Hsp90) is a key molecular chaperone involved in folding the synthesized protein and controlling protein quality. Conformational dynamics coupled to ATPase activity in N-terminal domain is essential for Hsp90's function ...
An Luo, Xinbo Li, Xuecheng Zhang, Huadong Zhan, Hewei Du, Yubo Zhang, Xiongbo Peng   +6 more
doaj   +1 more source

Conformational Dynamics of the RNA G-Quadruplex and its Effect on Translation Efficiency

Molecules, 2019
During translation, intracellular mRNA folds co-transcriptionally and must refold following the passage of ribosome. The mRNAs can be entrapped in metastable structures during these folding events.
T. Endoh, N. Sugimoto
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Quality Evaluation Based Simulation Selection (QEBSS) for analysis of conformational ensembles and dynamics of multidomain proteins

Communications Chemistry
Multidomain proteins containing both folded and intrinsically disordered regions are crucial for biological processes, but characterizing their conformational ensembles and dynamics remains challenging.
Amanda E. Sandelin, Ricky Nencini, Ekrem Yasar, Satoshi Fudo, Vassilis Stratoulias, Tommi Kajander, O. H. Samuli Ollila   +6 more
doaj   +1 more source

Linking time-series of single-molecule experiments with molecular dynamics simulations by machine learning

eLife, 2018
Single-molecule experiments and molecular dynamics (MD) simulations are indispensable tools for investigating protein conformational dynamics. The former provide time-series data, such as donor-acceptor distances, whereas the latter give atomistic ...
Yasuhiro Matsunaga, Yuji Sugita
doaj   +1 more source

Role of conformational dynamics in the evolution of novel enzyme function

Chemical Communications, 2018
Enzymes exist as a dynamic ensemble of conformations, each potentially playing a key role in substrate binding, the chemical transformation, or product release.
Miguel A. Maria-Solano, Eila Serrano-Hervás, A. Romero‐Rivera, Javier Iglesias-Fernández, Sílvia Osuna   +4 more
semanticscholar   +1 more source